25230-06-2Relevant articles and documents
Cross-Coupling of N-Heteroaryl Halides with Active Methylene Compounds in the Presence of Tetrakis(triphenylphosphine)palladium
Sakamoto, Takao,Katoh, Eisaku,Kondo, Yoshinori,Yamanaka, Hiroshi
, p. 1664 - 1668 (2007/10/02)
The cross-coupling of 3-iodo- and 3-bromopyridine with the carbanions derived from ethyl cyanoacetate and malononitrile in the presence of tetrakis(triphenylphosphine)palladium in 1,2-dimethoxyethane gave ethyl α-cyanopyridine-3-acetate and 3-pyridinemalononitrile in moderate yields.This palladium-catalyzed cross-coupling proceeded smoothly with halopyrimidines, haloquinolines, haloisoquinones, and also bromobenzene.Keywords - tetrakis(triphenylphosphine)palladium; aryl halide; N-heteroaryl halide; ethyl cyanoacetate; malononitrile; ethyl α-cyanoareneacetate; arenemalononitrile.