252953-46-1

Basic information

• Product Name: Carbamic acid, [(1S)-1-(hydroxymethyl)-1-methylpropyl]-, 1,1-dimethylethyl
• Synonyms: Carbamic acid, [(1S)-1-(hydroxymethyl)-1-methylpropyl]-, 1,1-dimethylethyl
• CAS NO: 252953-46-1
• Molecular Formula: C10H21NO3
• Molecular Weight: 203.27864
• Product Categories: N-BOC
• Mol File: 252953-46-1.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Carbamic acid, [(1S)-1-(hydroxymethyl)-1-methylpropyl]-, 1,1-dimethylethyl(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [(1S)-1-(hydroxymethyl)-1-methylpropyl]-, 1,1-dimethylethyl(252953-46-1)
• EPA Substance Registry System: Carbamic acid, [(1S)-1-(hydroxymethyl)-1-methylpropyl]-, 1,1-dimethylethyl(252953-46-1)

Safety Data

• Hazardous Substances Data: 252953-46-1(Hazardous Substances Data)

Upstream product

• 252953-44-9 (S)-N-(tert-butoxycarbonyl)-4-vinyl-2,2,4-trimethyl-3-oxazolidine 
• 252953-45-0 (S)-N-(tert-butoxycarbonyl)-4-ethyl-2,2,4-trimethyloxazolidine 

Downstream Products

• 151171-11-8 (S)-2-((tert-butoxycarbonyl)amino)-2-methylbutanoic acid 

Relevant articles and documents

Palladium-catalyzed ring opening of isoprene monoxide with nitrogen nucleophiles - Asymmetric synthesis of branched amino sugars

The Pd-catalyzed regio- and enantioselective ring opening of isoprene monoxide with primary amines as pronucleophiles is developed with good yield and enantioselectivity, constructing a quaternary stereocenter enantioselectively. This methodology was used

Preparation and synthetic applications of (S)- and (R)-N-boc-N, O- isopropylidene-α-methylserinals: Asymmetric synthesis of (S)- and (R)-2- amino-2-methylbutanoic acids (Iva)

This report describes an efficient and convenient large-scale synthesis procedure for (S)- and (R)-N-Boc-α-methylserinal acetonides (3 and 4) starting from (R)-2-methylglycidol 5. The application of both of these compounds as valuable chiral building blocks in the asymmetric synthesis of α-methylamino acids is also demonstrated by the synthesis of (S)- and (R)- isovalines (Iva) (6 and 7).