Carbamic acid, [(1S)-1-(hydroxymethyl)-1-methylpropyl]-, 1,1-dimethylethyl

Base Information

Chemical Name:Carbamic acid, [(1S)-1-(hydroxymethyl)-1-methylpropyl]-, 1,1-dimethylethyl
CAS No.:252953-46-1
Molecular Formula:C₁₀H₂₁NO₃
Molecular Weight:203.282
Hs Code.:
Mol file:252953-46-1.mol

Synonyms:Carbamic acid, [(1S)-1-(hydroxymethyl)-1-methylpropyl]-, 1,1-dimethylethyl

Suppliers and Price of Carbamic acid, [(1S)-1-(hydroxymethyl)-1-methylpropyl]-, 1,1-dimethylethyl

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 2 raw suppliers

Chemical Property of Carbamic acid, [(1S)-1-(hydroxymethyl)-1-methylpropyl]-, 1,1-dimethylethyl

Chemical Property:

PSA：58.56000
LogP:2.06300

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Carbamic acid, [(1S)-1-(hydroxymethyl)-1-methylpropyl]-, 1,1-dimethylethyl

There total 3 articles about Carbamic acid, [(1S)-1-(hydroxymethyl)-1-methylpropyl]-, 1,1-dimethylethyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 252953-45-0
(S)-N-(tert-butoxycarbonyl)-4-ethyl-2,2,4-trimethyloxazolidine

: 252953-46-1
tert-butyl (S)-[1-(hydroxymethyl)-1-methylpropyl]carbamate

Guidance literature:: With water; scandium tris(trifluoromethanesulfonate); In acetonitrile; at 25 ℃; for 24h;
DOI:10.1021/jo990957o

Reference yield:

: 252953-44-9
(S)-N-(tert-butoxycarbonyl)-4-vinyl-2,2,4-trimethyl-3-oxazolidine

: 252953-46-1
tert-butyl (S)-[1-(hydroxymethyl)-1-methylpropyl]carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: 96 percent / hydrogen / palladium on carbon / ethyl acetate / 12 h / 20 °C

2: 93 percent / water; Sc(OTf)3 / acetonitrile / 24 h / 25 °C

With water; hydrogen; scandium tris(trifluoromethanesulfonate); palladium on activated charcoal; In ethyl acetate; acetonitrile; 1: Catalytic hydrogenation / 2: Hydrolysis;
DOI:10.1021/jo990957o

Reference yield:

: 4-ethyl-4-methyl-2-oxo-oxazolidine-3-carboxylic acid tert-butyl ester

: 252953-43-8
tert-butyl (R)-[1-(hydroxymethyl)-1-methylpropyl]carbamate

: 252953-46-1
tert-butyl (S)-[1-(hydroxymethyl)-1-methylpropyl]carbamate

Guidance literature:: With caesium carbonate; In methanol; at 20 ℃; for 24h; Title compound not separated from byproducts;
DOI:10.1055/s-2005-918443