- 7-(1,1-Dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy) -3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine: A functionally selective γ-aminobutyric acidA (GABAA) α2/α3- subtype selective agonist that exhibits potent anxiolyti
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There is increasing evidence that compounds with selectivity for γ-aminobutyric acidA (GABAA) α2- and/or α3-subtypes may retain the desirable anxiolytic activity of nonselective benzodiazepines but possess an improved side effect pro
- Carling, Robert W.,Madin, Andrew,Guiblin, Alec,Russell, Michael G. N.,Moore, Kevin W.,Mitchinson, Andrew,Sohal, Bindi,Pike, Andrew,Cook, Susan M.,Ragan, Ian C.,McKernan, Ruth M.,Quirk, Kathleen,Ferris, Pushpinder,Marshall, George,Thompson, Sally Ann,Wafford, Keith A.,Dawson, Gerard R.,Atack, John R.,Harrison, Timothy,Castro, José L.,Street, Leslie J.
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p. 7089 - 7092
(2007/10/03)
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- Substituted triazolo-pyridazine derivative, pharmaceutical compositions made therefrom
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7-(1,1 -Dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine, and pharmaceutically acceptable salts thereof are selective ligands for GABAAreceptors useful in the treatment of disorders of t
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