253176-26-0

Basic information

• Product Name: 4-PYRIMIDIN-2-YL-PIPERAZINE-1-CARBONYL CHLORIDE
• Synonyms: 4-PYRIMIDIN-2-YL-PIPERAZINE-1-CARBONYL CHLORIDE
• CAS NO: 253176-26-0
• Molecular Formula: C₉H₁₁ClN₄O
• Molecular Weight: 226.66
• Mol File: 253176-26-0.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-PYRIMIDIN-2-YL-PIPERAZINE-1-CARBONYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-PYRIMIDIN-2-YL-PIPERAZINE-1-CARBONYL CHLORIDE(253176-26-0)
• EPA Substance Registry System: 4-PYRIMIDIN-2-YL-PIPERAZINE-1-CARBONYL CHLORIDE(253176-26-0)

Safety Data

• Hazardous Substances Data: 253176-26-0(Hazardous Substances Data)

Upstream product

• 20980-22-7 N-(2-pyridinyl)piperazine 
• 32315-10-9 bis(trichloromethyl) carbonate 
• 75-44-5 phosgene 

Relevant articles and documents

Design, synthesis and anti-inflammatory effects of novel 9-O-substituted-berberine derivatives

Berberine, an isoquinoline alkaloid in many medicinal herbs, has been found to possess broad pharmacological activities. A series of novel C-9-O-substituted-berberine derivatives have been synthesized and their anti-inflammatory effects evaluated both in vitro and in vivo. Compared to berberine, the new synthetic berberine derivatives 3i and 5e exhibit significantly improved inhibitory activities against the release of NO, TNF-α and IL-6. Furthermore, derivatives 3i and 5e were found to inhibit more effectively the migration of neutrophils and primitive macrophage in transgenic zebrafish larvae with injury-provoked inflammation. Pre-treatment with derivatives 3i or 5e could lead to a concentration-dependent decrease in nuclear factor-κB (NF-κB) p65 and NF-κB inhibitor α (IκBα) phosphorylation and inducible nitric oxide synthase (iNOS) expression in lipopolysaccharide (LPS)-induced RAW264.7 cells, which suggested that the anti-inflammatory activities of berberine derivatives 3i and 5e are related to their suppression of the NF-κB signal pathway.

Beta lactam compounds and their use as inhibitors of tryptase

Compounds of the formulas: are disclosed. These compounds inhibit tryptase as well as other enzyme systems or are selective tryptase inhibitors and are useful as antiinflammatory agents particularly in the treatment of chronic asthma.