- Visible-light-mediated generation of nitrile oxides for the photoredox synthesis of isoxazolines and isoxazoles
-
Visible-light photoredox catalysis enables the synthesis of biologically relevant isoxazolines and isoxazoles from hydroxyimino acids. The process shows broad functional group compatibility and mechanistic and computational studies support a visible-light-mediated generation of nitrile oxides by two sequential oxidative single electron transfer processes.
- Svejstrup, Thomas D.,Zawodny, Wojciech,Douglas, James J.,Bidgeli, Damon,Sheikh, Nadeem S.,Leonori, Daniele
-
p. 12302 - 12305
(2016/10/22)
-
- NOVEL 4,5-DIHYDROISOXAZOLES WITH ESTROGENIC ACTIVITY
-
This invention relates to novel 4,5-dihydroisoxazoles of formula (I), to their use as estrogen receptor modulators, and to methods of their preparation.
- -
-
Page/Page column 11; 53
(2009/06/27)
-
- Synthesis and evaluation of estrogen agonism of diaryl 4,5- dihydroisoxazoles, 3-hydroxyketones, 3-methoxyketones, and 1,3-diketones: A compound set forming a 4D molecular library
-
In this paper, the preparation and systematic evaluation of estrogen receptor α (ERα) and estrogen receptor β (ERβ) activities of some diaryl-1,3-diones and their synthetic intermediates, diaryl-4,5-dihydroisoxazoles, diaryl-3-hydroxyketones, diaryl-3-met
- Pulkkinen, Juha T.,Honkakoski, Paavo,Per?kyl?, Mikael,Berczi, Istvan,Laatikainen, Reino
-
supporting information; experimental part
p. 3562 - 3571
(2009/04/06)
-
- Generation of nitrile oxides from oxime derivatives by the oxidation with ammonium hexanitratocerate(IV)
-
Aromatic and aliphatic nitrile oxides are generated by the oxidation of α-hydroxyimino carboxylic acid with ammonium hexanitratocerate(IV). They react with olefinic and acetylenic dipolarophiles to give the corresponding cycloaddition products in good yield. The oxidation of α-oxo aldoximes also affords α-oxo carbonitrile oxides.
- Arai, Noriyoshi,Iwakoshi, Mitsuhiko,Tanabe, Katsuhiko,Narasaka, Koichi
-
p. 2277 - 2285
(2007/10/03)
-