- Straightforward access to pyrazines, piperazinones, and quinoxalines by reactions of 1,2-diaza-1,3-butadienes with 1,2-diamines under solution, solvent-free, or solid-phase conditions
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The preparation of tetrahydropyrazines, dihydropyrazines, pyrazines, piperazinones, and quinoxalines by 1,4-addition of 1,2-diamines to 1,2-diaza-1,3-butadienes bearing carboxylate, carboxamide, or phosphorylated groups at the terminal carbon and subseque
- Aparicio, Domitila,Attanasi, Orazio A.,Filippone, Paolino,Ignacio, Roberto,Lillini, Samuele,Mantellini, Fabio,Palacios, Francisco,De Los Santos, Jesus M.
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- HERBICIDAL COMPOUNDS
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The present invention relates to 6,6-dioxo-6-thia-1,4-diaza-naphthalene derivatives of formula (I) where R1, R2, R3a, R3b, R4 and R5 are as defined in claim 1; or a salt or N-oxide thereof.
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Page/Page column 39
(2010/12/17)
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- Dipeptidyl peptidase-IV inhibitors
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The invention provides compounds of Formula (I) or prodrugs thereof, or pharmaceutically acceptable salts of said compounds or prodrugs, or solvates of said compounds, prodrugs or salts, wherein A, N, X and R1 are as defined herein; pharmaceutical compositions thereof; and methods of using the pharmaceutical compositions for the treatment of diseases, including Type 2 diabetes, Type 1 diabetes, impaired glucose tolerance, hyperglycemia, metabolic syndrome (syndrome X and/or insulin resistance syndrome), glucosuria, metabolic acidosis, arthritis, cataracts, diabetic neuropathy, diabetic nephropathy, diabetic retinopathy, diabetic cardiomyopathy, obesity, conditions exacerbated by obesity, hypertension, hyperlipidemia, atherosclerosis, osteoporosis, osteopenia, frailty, bone loss, bone fracture, acute coronary syndrome, short stature due to growth hormone deficiency, infertility due to polycystic ovary syndrome, anxiety, depression, insomnia, chronic fatigue, epilepsy, eating disorders, chronic pain, alcohol addiction, diseases associated with intestinal motility, ulcers, irritable bowel syndrome, inflammatory bowel syndrome; short bowel syndrome; and the prevention of disease progression in Type 2 diabetes.
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Page/Page column 27
(2010/02/14)
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- Different behavior of the reaction between 1,2-diaza-1,3-butadienes and 1,2-diamines under solvent or solvent-free conditions
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New piperazinones are obtained in satisfactory yields by reaction of 1,2-diaza-1,3-butadienes with 1,2-diamines under solvent-free conditions. In polar solvents, the same reagents give rise to interesting dihydropyrazines and then to pyrazines by oxidatio
- Attanasi, Orazio A.,De Crescentini, Lucia,Favi, Gianfranco,Filippone, Paolino,Lillini, Samuele,Mantellini, Fabio,Santeusanio, Stefania
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p. 1474 - 1476
(2007/10/03)
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