Successive iodine-magnesium or -copper exchange reactions for the selective functionalization of polyhalogenated aromatics
(Matrix presented) The presence of an electron-withdrawing group or chelating group was found to direct the halogen-copper and halogen-magnesium exchange with various di- or trihalogenated aromatics. Starting with a triiodobenzoate derivative, a range of
Yang, Xiaoyin,Rotter, Thomas,Piazza, Claudia,Knochel, Paul
Regioselective Iodine/Zinc Exchange for the Selective Functionalization of Polyiodinated Arenes and Heterocycles in Toluene
Regioselective I/Zn-exchange reactions were performed on polyiodinated arenes or heterocycles within 20 minutes at 0-25 °C using the bimetallic combination pTol2Zn2LiOR [R = (CH2)2N(Me)(CH2)2NMe2] in toluene. The resulting diaryl- or diheteroarylzincs reacted well with allylic bromides and acyl chlorides to provide functionalized (hetero)- aryl iodides in good yields.
Sanchez, Florian,Desaintjean, Alexandre,Danton, Fanny,Knochel, Paul
supporting information
p. 4662 - 4671
(2021/09/06)
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