256224-02-9

Basic information

• Product Name: 2-AMINO-3'-O-(2-METHOXYETHYL)ADENOSINE
• Synonyms: 2-AMINO-3'-O-(2-METHOXYETHYL)ADENOSINE;3'-O-(2-Methoxyethyl)-2-aminoadenosine
• CAS NO: 256224-02-9
• Molecular Formula: C13H20N6O5
• Molecular Weight: 340.34
• Mol File: 256224-02-9.mol

Chemical Properties

• Boiling Point: 734.5±70.0 °C(Predicted)
• Appearance: /
• Density: 1.81±0.1 g/cm3(Predicted)
• PKA: 12.95±0.70(Predicted)
• CAS DataBase Reference: 2-AMINO-3'-O-(2-METHOXYETHYL)ADENOSINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-3'-O-(2-METHOXYETHYL)ADENOSINE(256224-02-9)
• EPA Substance Registry System: 2-AMINO-3'-O-(2-METHOXYETHYL)ADENOSINE(256224-02-9)

Safety Data

• Hazardous Substances Data: 256224-02-9(Hazardous Substances Data)

Usage

Structure

Modified nucleoside with an adenosine base and a 2-methoxyethyl group attached to the 3' position.

Therapeutic Uses

Anticancer agent
Modulator of immune responses

Research Focus

Regulation of RNA metabolism
Potential target for drug development

Biomedical Applications

Various potential uses in medicine

Ongoing Research

Aimed at elucidating its potential uses and mechanisms of action.

Upstream product

• 16427-44-4 2-methoxyethyl methanesulfonate 
• 2096-10-8 adenosine-2-amine 
• 6482-24-2 2-Bromoethyl methyl ether 
• 620630-82-2 1,2 5,6-O-di(isopropylidene)-α-D-allofuranose 

Relevant articles and documents

An improved process for the manufacture of 5′-O-(4,4′-dimethoxytrityl)-N2-isobutyryl-2′-O-(2-methoxyethyl)guanosine

A revised, optimized process for the manufacture of 5′-O-(4,4′-dimethoxytrityl)-N2-isobutyryl-2′-O-(2- methoxyethyl)guanosine (MOE G PNS) that controls critical impurities to less than 0.2% was developed. The 2′-O-alkylation of 2,6-diaminopurine riboside

A 3' - oxygen - methoxy ethyl nucleoside preparation method (by machine translation)

The invention discloses a 3' - oxygen - methoxy ethyl nucleoside of the preparation method. The method includes the steps of: (1) the structure of the compound represented by the formula B with the silanized protection base by condensation to obtain the structure of a compound represented by the formula C; the base selected from thymine, 5 - methyl cytosine, adenine or 2, 6 - II aminopurine; and (2) the structure of the compound is shown as formula C by alkaline hydrolysis reaction to obtain the structure shown in formula A 3' - oxygen - methoxy ethyl nucleoside. (by machine translation)

Process research on the preparation of DMT protected 2′-O- methoxyethylguanosine for oligonucleotide synthesis in therapeutic applications

An optimized process to synthesize DMT protected 2′-O- methoxyethylguanosine is described. A key step involves the enzymatic deamination of a mixture of alkylated products to selectively afford the desired material without resorting to chromatography for purification. This approach was scaled up to kilogram quantities for use in oligonucleotide therapeutics. Copyright Taylor & Francis Group, LLC.

Synthesis study of 2′-O-(2-methoxyethyl)-purine derivatives

Alkylation of adenosine and 2-aminoadenosine was studied in dimethylsulfoxide with application of 1-methanesulfonyloxy-2-methoxyethane as an alkylating agent and t-BuOK, KOH and NaH as bases under mild heating. Using new reaction conditions, the improved synthesis of 2′-O-MOE-purine derivatives is described. Copyright Taylor & Francis Group, LLC.