16427-44-4

Usage

Uses

Used in Polymer Industry:
METHANESULFONIC ACID 2-METHOXYETHYL ESTER is used as a reagent for the ring-opening polymerization of lactide. It facilitates the formation of polylactic acid (PLA), a biodegradable and biocompatible polymer with applications in packaging, agriculture, and medical devices.
Used in Pharmaceutical Industry:
METHANESULFONIC ACID 2-METHOXYETHYL ESTER is used as an intermediate in the synthesis of acetylcholine receptor ligands. These ligands are essential for the development of drugs targeting neurological disorders, such as Alzheimer's disease and myasthenia gravis, due to their role in the regulation of neurotransmission.

InChI:InChI=1/C4H10O4S/c1-7-3-4-8-9(2,5)6/h3-4H2,1-2H3

Upstream product

• 109-86-4 2-methoxy-ethanol 
• 124-63-0 methanesulfonyl chloride 
• 616-47-7 1-methyl-1H-imidazole 

Downstream Products

• 65275-38-9 β-Methoxyethyl(phenyl)selenid 
• 109-86-4 2-methoxy-ethanol 
• 169616-09-5 dimethyl 3,4-bis-(2-methoxyethoxy)-1-benzylpyrrole-2,5-dicarboxylate 
• 484679-02-9 N,N-Bis(2-(2-methoxyethoxy)ethyl)benzene amine 
• 303197-30-0 3'-O-methoxyethyladenosine 
• 1062491-29-5 C₁₆H₂₅N₅O₆ 
• 1062491-27-3 C₁₆H₂₅N₅O₆ 
• 168427-74-5 2'-O-(2-methoxyethyl)adenosine 
• 256224-02-9 3'-O-methoxyethyl-2,6-diaminopurine riboside 
• 847647-19-2 C₁₆H₂₆N₆O₆ 
• 256224-13-2 2'-O-(2-methoxyethyl)-2,6-diaminopurine riboside 
• 75942-40-4 3,6-bis(2-methoxy-ethoxy)phthalodinitrile 
• 637739-85-6 1-(2-methoxyethyl)-3-methylimidazolium methanesulfonate 
• 649724-45-8 9,9-di(2-methoxyethyl)-2-diphenylaminofluorene 

Relevant academic research and scientific papers

Squaraines as Fluoro-Chromogenic Probes for Thiol-Containing Compounds and Their Application to the Detection of Biorelevant Thiols

A highly selective colorimetric chemodosimeter for thiol-containing compounds in aqueous solutions is reported. The design protocol makes use of a highly specific reaction between thiols and the electrophilic four-membered ring of highly colored, fluoresc

Study on the thermodynamic properties of ether-functionalized imidazolium-based ionic liquids

Ether-functionalized imidazolium-based ionic liquids (EFIILs) exhibit extremely high SO2 solubility. In this paper, a series of EFIILs were prepared, and their structures were confirmed by 1H NMR. The thermodynamic properties of EFIILs, such as density, viscosity and surface tension, were measured from (298.15 to 343.15) K at atmospheric pressure. The molecular volume, coefficient of thermal expansion, standard entropy, surface entropy, and surface enthalpy were calculated from the experimental data. The results indicate that density, viscosity and surface tension of the specific EFIILs show linear decline as temperature rises, and decrease with the increase of ether chain length of the cation at the same temperature. The surface properties of EFIILs were also discussed systematically.

Functional magnetic mesoporous silica microparticles capped with an azo-derivative: A promising colon drug delivery device

Magnetic micro-sized mesoporous silica particles were used for the preparation of a gated material able to release an entrapped cargo in the presence of an azo-reducing agent and, to some extent, at acidic pH. The magnetic mesoporous microparticles were loaded with safranin O and the external surface was functionalized with an azo derivative 1 (bearing a carbamate linkage) yielding solid S1. Aqueous suspensions of S1 at pH 7.4 showed negligible safranin O release due to the presence of the bulky azo derivative attached onto the external surface of the inorganic scaffold. However, in the presence of sodium dithionite (azoreductive agent), a remarkable safranin O delivery was observed. At acidic pH, a certain safranin O release from S1 was also found. The pH-triggered safranin O delivery was ascribed to the acid-induced hydrolysis of the carbamate moiety that linked the bulky azo derivatives onto the mesoporous inorganic magnetic support. The controlled release behavior of S1 was also tested using a model that simulated the gastro intestinal tract.

Carbon Acidity. 74. The Effects of Hetero-Substituted Pendant Groups on Carbanion Reactivity. Solvent-Separated-Contact Ion Pair Equilibria and Relative pKLi/THF's for 9-Substituted Fluorenyllithiums in Tetrahydrofuran. The Importance of Internal Chelation

For a series of 9-substituted fluorenyllithiums (substituents: CH3OCH2CH2-, 1; (CH3)2NCH2CH2-, 2; CH3SCH2CH2-, 3; CH3CH2CH2CH2-, 4; CH3OCH2CH2OCH2CH2-, 5; H-, 6) the equilibria between solvent-separated ion pairs (SSIP's) and contact ion pairs (CIP's) have been determined in tetrahydrofuran (THF) with UV-vis spectroscopy.Either oxygen or nitrogen in the pendant group favors CIP formation by the ability of the heteroatom to form an internal chelate.This chelation can lead to over 100-fold shifts in the relative stabilities of SSIP's and CIP's.Thermodynamic parameters (ΔHo and ΔSo) for the equilibria are presented and indicate that formation of the CIP releases coordinating solvent - this effect is greater if the CIP forms an internal chelate.The pKLi/THF's, pKli/THF(SSIP)'s and pKli/THF(CIP)'s of the substituted fluorenes (relative to fluorene, pKLi/THF(SSIP) = 22.9) are presented and show that oxygen or nitrogen in the pendant group stabilizes the SSIP's somewhat (ca. 0.5 pK units) but stabilizes the CIP's dramatically (> 2 pK units).Although sulfur substitution does not lead to internal chelates, it does lead to a substantial stabilization in the SSIP.Finally, neither aggregation nor SSIP internal chelation appears to be important in these fluorenyllithium derivatives; that is, internal chelation can be important in CIP's but is much less important in SSIP's for this class of organolithium compounds.

Isolation of highly pure erlotinib hydrochloride by recrystallization after nucleophilic substitution of an impurity with piperazine

Optimized synthesis and purification of erlotinib hydrochloride (N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazoline-4-amine hydrochloride) were studied. Highly polar piperazine was used in a nucleophilic substitution reaction with the chlorinated intermediate byproduct N-(3-ethynylphenyl)-6(2- chloroethoxy)-7-(2-methoxyethoxy)quinazolin-4-amine hydrochloride. As a result, N-(3-ethynylphenyl)-6(2-chloroethoxy)-7-(2-methoxyethoxy)quinazolin-4-amine hydrochloride was completely transformed to N-(3-ethynylphenyl)-6(2- piperzinoethoxy)-7-(2-methoxyethoxy)quinazolin-4-amine hydrochloride. The polarity of N-(3-ethynylphenyl)-6(2-piperzinoethoxy)-7-(2-methoxyethoxy) quinazolin-4-amine hydrochloride was changed, and its molecule was enlarged. It was easy to remove this larger, more polar, compound by recrystallization. Highly pure erlotinib hydrochloride was obtained with low impurity content (99.9 %.

Pyridazinone compound, preparation method thereof, pharmaceutical composition and its use

The present invention is in the scope of the field of pharmaceutical chemistry. Specifically, the present invention relates to pyridazinone compounds of formula (I) or isomers, pharmaceutically acceptable salts, esters, prodrugs or solvates thereof, preparation method, pharmaceutical compositions thereof and use in manufacture of tyrosine kinase inhibitors, specially c-Met inhibitors. Said compounds or pharmaceutical compositions are used to prevent and/or treat tumor diseases related to c-Met abnormality as tyrosine kinase inhibitors, specially c-Met inhibitors.

SILICON PHTHALOCYANINE COMPLEX, PREPARATION METHOD AND MEDICINAL APPLICATION THEREOF

The present invention relates to a silicon phthalocyanine complex, the preparation method and the medicinal application thereof. The present invention particularly relates to a silicon phthalocyanine complex of formula (I), the preparation method thereof and a pharmaceutical composition comprising the same, as well as the use thereof as a photosensitizer, in particular the use in the treatment of cancers, wherein each substituent in formula (I) is the same as defined in the description.

Selective and sensitive chromogenic detection of trivalent metal cations in water

An azopyridine derivative for the selective and sensitive chromogenic detection of trivalent metal cations in water is described.

Erlotinid hydrochloride method for the preparation of key intermediate

The invention discloses a preparation method of an erlotinib hydrochloride key intermediate 4-chloro-6,7-di(2-methoxyethoxy)quinazoline, which comprises the following steps: reacting the raw material ethyl 3,4-dihydroxybenzoate with ethyl 2-methoxysulfonate, nitrating, reducing, cyclizing and chlorinating to obtain the key intermediate 4-chloro-6,7-di(2-methoxyethoxy)quinazoline. The method has the advantages of mild reaction conditions, low cost, high purity and high total yield (up to 74.8%), and can easily implement industrial production.

Ether-based bis-imidazole ionic liquid used for absorbing SO2, preparation method and application method thereof

The invention relates to ether-based bis-imidazole ionic liquid used for absorbing SO2. The ether-based bis-imidazole ionic liquid has the advantages of high absorption capacity, good stability and recyclable performance, no secondary pollution is generated during a desulphurization process, usage of the ether-based bis-imidazole ionic liquid for desulphurization is a technical method having industrial application potential for high-efficiency removal of SO2. According to a preparation method, process is simple, stability of the preparation process is high, and repeatability is good.