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256224-13-2

2-AMINO-2'-O-(2-METHOXYETHYL)ADENOSINE is a chemical compound that belongs to the class of adenosine derivatives. It is a modified form of adenosine, where the hydroxyl group at the 2' position is substituted with a 2-methoxyethyl group. This modification enhances the compound's stability and can potentially alter its biological activity. Adenosine derivatives, including 2-amino-2'-O-(2-methoxyethyl)adenosine, are known for their role in various physiological processes, including neurotransmission, energy metabolism, and immune response.

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  • 256224-13-2 Structure

  • Basic information

    1. Product Name: 2-AMINO-2'-O-(2-METHOXYETHYL)ADENOSINE
    2. Synonyms: 2-AMINO-2'-O-(2-METHOXYETHYL)ADENOSINE;2'-O-(2-Methoxyethyl)-2-aminoadenosine
    3. CAS NO:256224-13-2
    4. Molecular Formula: C13H20N6O5
    5. Molecular Weight: 340.34
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 256224-13-2.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 2-AMINO-2'-O-(2-METHOXYETHYL)ADENOSINE(CAS DataBase Reference)
    10. NIST Chemistry Reference: 2-AMINO-2'-O-(2-METHOXYETHYL)ADENOSINE(256224-13-2)
    11. EPA Substance Registry System: 2-AMINO-2'-O-(2-METHOXYETHYL)ADENOSINE(256224-13-2)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 256224-13-2(Hazardous Substances Data)

256224-13-2 Usage

Uses

Used in Pharmaceutical Industry:
2-AMINO-2'-O-(2-METHOXYETHYL)ADENOSINE is used as a therapeutic agent for the treatment of neurological and cardiovascular disorders. Its potential applications include modulating neurotransmission, improving energy metabolism, and regulating immune response.
Used in Research Applications:
2-AMINO-2'-O-(2-METHOXYETHYL)ADENOSINE is used as a research tool to study the role of adenosine derivatives in various physiological processes and their potential therapeutic applications. It can help researchers understand the mechanisms of action and develop new drugs targeting these pathways.

Check Digit Verification of cas no

The CAS Registry Mumber 256224-13-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,5,6,2,2 and 4 respectively; the second part has 2 digits, 1 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 256224-13:
(8*2)+(7*5)+(6*6)+(5*2)+(4*2)+(3*4)+(2*1)+(1*3)=122
122 % 10 = 2
So 256224-13-2 is a valid CAS Registry Number.

256224-13-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name (2R,3R,4R,5R)-5-(2,6-diaminopurin-9-yl)-2-(hydroxymethyl)-4-(2-methoxyethoxy)oxolan-3-ol

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:256224-13-2 SDS

256224-13-2Relevant articles and documents

An improved process for the manufacture of 5′-O-(4,4′-dimethoxytrityl)-N2-isobutyryl-2′-O-(2-methoxyethyl)guanosine

McPherson, Andrew K.,Capaldi, Daniel,Chen, Lijian,Olsen, Philip

, p. 2583 - 2590 (2020/12/29)

A revised, optimized process for the manufacture of 5′-O-(4,4′-dimethoxytrityl)-N2-isobutyryl-2′-O-(2- methoxyethyl)guanosine (MOE G PNS) that controls critical impurities to less than 0.2% was developed. The 2′-O-alkylation of 2,6-diaminopurine riboside

Synthesis and cellular activity of stereochemically-pure 2′-O-(2-methoxyethyl)-phosphorothioate oligonucleotides

Li,Lightfoot,Halloy,Malinowska,Berk,Behera,Schümperli,Hall

supporting information, p. 541 - 544 (2017/01/13)

Stereochemically-pure 2′-O-(2-methoxyethyl)-phosphorothioate (PS-MOE) oligonucleotides were synthesized from new chiral oxazaphospholidine-containing nucleosides. Thermal stability studies showed that the incorporation of Rp-PS linkages increased RNA-binding affinity. In cells, a full Rp-PS-MOE splice-switching oligonucleotide targeting part of the ferrochelatase gene was more potent than its Sp-PS counterpart, but of similar potency to the stereorandom PS-parent sequence.

2'-O-MOE-3'-H-phosphorothioate nucleoside monomer and synthetic method thereof

-

Paragraph 0051; 0052, (2017/01/23)

The invention discloses 2'-O-MOE-3'-H-phosphorodithioate ribonucleotide and 2'-O-MOE-3'-H-phosphorothioate ribonucleotide and precursor compounds thereof, preparation methods and applications of the 2'-O-MOE-3'-H-phosphorodithioate ribonucleotide and the

Process research on the preparation of DMT protected 2′-O- methoxyethylguanosine for oligonucleotide synthesis in therapeutic applications

Taj, Shabbir Ali S.,Narayanan,Meenakshi, S. Suman,Sanghvi, Yogesh S.,Ross, Bruce S.,Ravikumar, Vasulinga T.

, p. 1024 - 1033 (2008/12/22)

An optimized process to synthesize DMT protected 2′-O- methoxyethylguanosine is described. A key step involves the enzymatic deamination of a mixture of alkylated products to selectively afford the desired material without resorting to chromatography for purification. This approach was scaled up to kilogram quantities for use in oligonucleotide therapeutics. Copyright Taylor & Francis Group, LLC.

Synthesis study of 2′-O-(2-methoxyethyl)-purine derivatives

Sivets, Grigorii G.

, p. 1237 - 1240 (2008/09/18)

Alkylation of adenosine and 2-aminoadenosine was studied in dimethylsulfoxide with application of 1-methanesulfonyloxy-2-methoxyethane as an alkylating agent and t-BuOK, KOH and NaH as bases under mild heating. Using new reaction conditions, the improved synthesis of 2′-O-MOE-purine derivatives is described. Copyright Taylor & Francis Group, LLC.

Process development for the synthesis of 5′-O-(4,4′ -dimethoxytrityl)-N2-isobutyryl-2′-O-(2-methoxyethyl) -guanosine - A potential precursor for the second generation antisense oligonucleotides: An improved process for the preparation of 2′-O-a

Taj, Shabbir Ali S.,Gurumurthy,Suresh,Narayanan,Meenakshi, S. Suman,Sanghvi, Yogesh S.

, p. 1327 - 1330 (2007/10/03)

An efficient four step process for the preparation of 5′ -O-(4,4′-dimethoxytrityl)-N2-isobutyryl-2′-O-(2-methoxyethyl) -guanosine 1 was developed. Direct 2′-O-alkylation of 2,6-diaminopurine riboside 2 was accomplished via inexpensive and commercially ava

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