- First enantiospecific synthesis of the antitumor marine sponge metabolite (-)-15-oxopuupehenol from (-)-sclareol
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(Chemical Equation Presented) A new route toward puupehenone-related bioactive metabolites from (-)-sclareol, based on the palladium(II)-mediated diastereoselective cyclization of a drimenylphenol, is described. Utilizing this, the first enantiospecific synthesis of the antitumor and antimalarial (-)-15-oxopuupehenol, together with improved syntheses of (+)-puupehenone, (+)-puupehedione, and (+)-15-cyanopuupehenone, were accomplished.
- Alvarez-Manzaneda,Chahboun,Barranco Perez,Cabrera,Alvarez,Alvarez-Manzaneda
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p. 1477 - 1480
(2007/10/03)
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- Synthesis and antitumor activity of puupehedione and related compounds
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The first enantiospecific synthesis of bioactive marine puupehedione (2) and related compounds from (-)-sclareol (11) is reported. The antitumor activity of these compounds was assayed and compared with that of the natural products.
- Barrero, Alejandro F.,Alvarez-Manzaneda, Enrique J.,Chahboun, Rachid,Cortes,Armstrong
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p. 15181 - 15208
(2007/10/03)
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