- Design, synthesis and molecular docking of novel diarylcyclohexenone and diarylindazole derivatives as tubulin polymerization inhibitors
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New target compounds were designed as inhibitors of tubulin polymerization relying on using two types of ring B models (cyclohexenone and indazole) to replace the central ring in colchicine. Different functional groups (R1) were attached to man
- Ahmed, Riham I.,Osman, Essam Eldin A.,Awadallah, Fadi M.,El-Moghazy, Samir M.
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p. 176 - 188
(2017/11/21)
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- Activated fly ash catalyzed facile synthesis of novel spiro imidazolidine derivatives as potential antibacterial and antifungal agents
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An array of novel spiro imidazolidine derivatives was synthesized in dry media and was screened for their anti-microbial activities. Structure-activity relationship results revealed that compounds 22, 23 against P.aeruginosa, 24 against S.aureus, 24, 25 against K.pneumonia, 27 against S.aureus, β-H.streptococcus, 29 against M.luteus, K.pneumonia, 29, 30 against P.vulgaris exhibited excellent antibacterial activity at a minimum inhibitory concentration (MIC) value of 6.25 μg/mL. Compound 23 against M.gypseum, 25, 29 against Candida 6 and 29, 30 against C.albicans revealed excellent antifungal activity at a MIC value of 6.25 μg/mL.
- Kanagarajan,Thanusu,Gopalakrishnan
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p. 280 - 287
(2011/10/18)
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- Synthesis, spectral analysis, and in vitro microbiological evaluation of ethyl 7,9-diaryl-1, 4-diazaspiro[4.5]dec-9-ene-6-carboxylates as a new class of antibacterial and antifungal agents
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A series of novel ethyl 7,9-diaryl-1,4-diazaspiro[4.5]dec-9-ene-6- carboxylates was synthesized by the reaction of ethyl 4,6-diaryl-2-oxocyclohex- 3-ene-1-carboxylates with ethylenediamine in the presence of p-toluenesulfonic acid without a solvent under focused microwave irradiation. The title compounds were screened for their antimicrobial activities against a spectrum of clinically isolated microorganisms.
- Thanusu,Kanagarajan,Gopalakrishnan
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p. 575 - 583
(2012/01/19)
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- Microwave assisted rapid and efficient. synthesis of new 3-ethoxy-4,6-diaryl-4,5- Dihydro-2,1-benzisoxazoles
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A simple, extremely fast and efficient synthesis of new 3- ethoxy-4,6-diaryl-4,5-dihydro2,l-benzisoxazoles has been achieved under microwave irradiation.
- Rajanarenda,Rao,Raju
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experimental part
p. 749 - 753
(2009/12/28)
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