259809-24-0

Basic information

• Product Name: Thiazolo[5,4-c]pyridine, 4,5,6,7-tetrahydro-5-methyl-
• Synonyms: Thiazolo[5,4-c]pyridine, 4,5,6,7-tetrahydro-5-methyl-;4,5,6,7-Tetrahydro-5-Methylthiazolo[5,4-c]pyridine;5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine
• CAS NO: 259809-24-0
• Molecular Formula: C₇H₁₀N₂S
• Molecular Weight: 154.23
• Mol File: 259809-24-0.mol

Chemical Properties

• Boiling Point: 245.4±30.0 °C(Predicted)
• Appearance: /
• Density: 1.186±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 7.06±0.20(Predicted)
• CAS DataBase Reference: Thiazolo[5,4-c]pyridine, 4,5,6,7-tetrahydro-5-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Thiazolo[5,4-c]pyridine, 4,5,6,7-tetrahydro-5-methyl-(259809-24-0)
• EPA Substance Registry System: Thiazolo[5,4-c]pyridine, 4,5,6,7-tetrahydro-5-methyl-(259809-24-0)

Safety Data

• Hazardous Substances Data: 259809-24-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Thiazolo[5,4-c]pyridine, 4,5,6,7-tetrahydro-5-methylis used as a key intermediate in the synthesis of various pharmaceutical compounds for its unique chemical properties and reactivity. Its ability to form stable complexes with other molecules makes it a promising candidate for the development of new drugs with potential therapeutic applications.
Used in Chemical Synthesis:
In the field of chemical synthesis, Thiazolo[5,4-c]pyridine, 4,5,6,7-tetrahydro-5-methylserves as a valuable building block for the creation of complex organic molecules. Its unique structure and reactivity allow for the formation of new substances with potential applications in various industries, including materials science, agrochemicals, and specialty chemicals.
Used in Research and Development:
Thiazolo[5,4-c]pyridine, 4,5,6,7-tetrahydro-5-methylis utilized in research and development settings to explore its potential applications and properties. Scientists and researchers investigate its chemical behavior, reactivity, and interactions with other compounds to gain insights into its possible uses and to develop new synthetic routes for its production.
Used in Material Science:
In material science, Thiazolo[5,4-c]pyridine, 4,5,6,7-tetrahydro-5-methylcan be employed as a component in the development of advanced materials with specific properties. Its unique structure and reactivity may contribute to the creation of materials with improved performance characteristics, such as enhanced stability, reactivity, or selectivity in various applications.

Downstream Products

• 720720-96-7 5-methyl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridine-2-carboxylic acid hydrochloric acid salt 
• 758685-72-2 5-methyl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridine-2-carboxylic acid 
• 480449-70-5 edoxaban 
• 480449-71-6 [14C]-Edoxaban tosylate 
• 852291-40-8 4,5,6,7-tetrahydro-5-methylthiazolo[5,4-c]pyridine p-toluenesulfonate 

Relevant articles and documents

Method for preparing edoxaban from trichloroacetophenone onium salt derivatives

The invention provides a method for preparing edoxaban by using 2, 2, 2-trichloro-1-(4, 5, 6, 7-tetrahydro-5-methylthiazolo[5, 4-c]pyridinium-1-yl) ethanone chloride. The preparation method comprisesthe following steps: preparing 2, 2, 2-trichloro-1-(4, 5, 6, 7-tetrahydro-5-methylthiazolo[5, 4-c]pyridinium-1-yl) ethanone chloride, namely 109C5-11; the invention discloses a preparation method of N1[(1S, 2R, 4S)-2-amino-4-[(dimethylamino) carbonyl]cyclohexyl]-N2(5-chloro-2-pyridyl) oxalamide dimesylate, namely 109T2-31. The 109C5-11 is used as an acylation reagent to prepare the edoxaban with 109T2-31. The preparation method comprises the following steps: preparing the edoxaban by using the 109C5-11 as the acylation reagent; the novel method overcomes the defect that expensive condensing agents EDCI.HCl and activating agents HOBt need to be used in the prior art. The new method provided by the invention is beneficial to more economically and more efficiently realizing industrial scale production of the Edoxaban p-toluenesulfonate hydrate.

Preparation method of edoxaban

The invention relates to a new preparation route and a new method for a p-toluenesulfonic acid edoxaban hydrate and intermediates thereof. The new method comprises the steps that a high-reactivity compound 109A4x is prepared; a compound 109C6x is prepared by using a new synthesizing method; new compounds 109E8-01, 109E9x and 109T7-01 are prepared; the p-toluenesulfonic acid edoxaban hydrate is prepared by using the intermediates. By using the new method and the new route, the reaction step of copious cooling is omitted, and dangerous elemental sulfur, high-risk n-butyllithium and high-risk azides are prevented from being used. In a word, by means of the method, the p-toluenesulfonic acid edoxaban hydrate and the key intermediates thereof are more easily and safely prepared at a lower coston an industrialization scale.