259860-01-0

Basic information

• Product Name: 7-Chloro-6-fluoro indole
• Synonyms: 7-Chloro-6-fluoro indole;7-Chloro-5-fluoro-1H-indole
• CAS NO: 259860-01-0
• Molecular Formula: C8H5ClFN
• Molecular Weight: 169.5834032
• Mol File: 259860-01-0.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 7-Chloro-6-fluoro indole(CAS DataBase Reference)
• NIST Chemistry Reference: 7-Chloro-6-fluoro indole(259860-01-0)
• EPA Substance Registry System: 7-Chloro-6-fluoro indole(259860-01-0)

Safety Data

• Hazardous Substances Data: 259860-01-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
7-Chloro-6-fluoro indole serves as a crucial building block in the synthesis of various pharmaceutical products, particularly those with antibacterial and antiviral properties. Its presence in the molecular structure of these drugs enhances their efficacy and broadens their spectrum of activity against pathogens.
Used in Agrochemical Industry:
In the agrochemical sector, 7-Chloro-6-fluoro indole is utilized as an intermediate in the development of compounds that protect crops from pests and diseases. Its ability to be incorporated into complex molecules allows for the creation of novel agrochemicals with improved performance and selectivity.
Used in Medicinal Chemistry:
7-Chloro-6-fluoro indole is employed as a valuable intermediate in medicinal chemistry for the introduction of fluorine and chlorine atoms into larger organic molecules. This modification can significantly alter the pharmacokinetic and pharmacodynamic properties of these molecules, leading to improved drug candidates with enhanced stability, bioavailability, and target affinity.

Upstream product

• 201849-14-1 2-bromo-6-chloro-4-fluorophenylamine 
• 259860-03-2 7-chloro-5-fluoroindole-2,3-dione 

Relevant articles and documents

INHIBITORS OF INFLUENZA VIRUS REPLICATION, APPLICATION METHODS AND USES THEREOF

A class of compounds as inhibitors of influenza virus replication, preparation methods thereof, pharmaceutical compositions containing these compounds, and uses of these compounds and pharmaceutical compositions thereof in the treatment of influenza.

Indoline derivatives as 5-HT2B and or 5-HTC receptor ligands

For use in therapy a chemical compound of formula (I), wherein R1to R3are independently selected from hydrogen and alkyl; R4to R7are independently selected from hydrogen, halogen, hydroxy, alkyl, aryl, heterocyclyl, alkoxy, aryloxy, alkylthio, arylthio, alkylsulfoxyl, alkylsulfonyl, arylsulfoxyl, arylsulfonyl, amino, monoalkylamino, dialkylamino, nitro, cyano, carboxaldehyde, alkylcarbonyl, arylcarbonyl, aminocarbonyl, monoalkylaminocarbonyl, dialkylaminocarbonyl, alkoxycarbonylamino, aminocarbonyloxy, monoalkylaminocarbonyloxy, dialkylaminocarbonyloxy, monoalkylaminocarbonylamino and dialkylaminocarbonylamino, wherein at least one of R4to R7is a substituent group other than hydrogen, and pharmaceutically acceptable salts and prodrugs thereof, particularly for the treatment of disorders of the central nervous system; damage to the central nervous system; cardiovascular disorders; gastrointestinal disorders; diabetes insipidus, and sleep apnea, and especially for the treatment of obesity; chemical compounds of formula (I) other than compounds wherein R7is hydroxy.