260562-59-2Relevant articles and documents
ANTI-VIRAL AND ANTI-TUMORAL COMPOUNDS
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Paragraph 00470; 00483-00486, (2022/03/07)
Disclosed herein are 3, 4–didehydro- and 3′-deoxy-3, 4–didehydro-compounds and pharmaceutical compositions thereof. Methods of use of these pharmaceutical compositions include those for treating diseases including virus-induced diseases, cancer, autoimmune diseases, immune disorders, and bacterial-associated diseases or infections, or combinations thereof. Examples of viral-induced diseases include viral infections by RNA or DNA viruses, for example SAR-CoV-2, EBV, and BKV. P-595088-PC
Phosphonomethyl Oligonucleotides as Backbone-Modified Artificial Genetic Polymers
Liu, Chao,Cozens, Christopher,Jaziri, Faten,Rozenski, Jef,Maréchal, Amandine,Dumbre, Shrinivas,Pezo, Valérie,Marlière, Philippe,Pinheiro, Vitor B.,Groaz, Elisabetta,Herdewijn, Piet
supporting information, p. 6690 - 6699 (2018/05/15)
Although several synthetic or xenobiotic nucleic acids (XNAs) have been shown to be viable genetic materials in vitro, major hurdles remain for their in vivo applications, particularly orthogonality. The availability of XNAs that do not interact with natu
Synthesis and anti-HIV evaluation of 2',3'-dideoxy imidazo- and ν- triazolo[4,5-d]pyridazine nucleosides
Bussolari, Jacqueline C.,Panzica, Raymond P.
, p. 2373 - 2379 (2007/10/03)
The syntheses of the 2'-deoxy and 2',3'-dideoxynucleosides of 2,8-diaza- 3-deazainosine and the 2',3'-dideoxynucleoside of 2-aza-3-deazainosine were achieved and the pathways leading to these novel nucleosides are described. The preparation of the 2',3'-dideoxynucleoside (1) of 2-aza-3-deazainosine involved deoxygenation of the 2'-deoxy-3'-imidazolide intermediate with n- Bu3SnH and AIBN. The latter nucleoside was synthesized from the known 2'- deoxy derivative of 2-aza-3-deazainosine. The three-step synthesis of 1 from the 2'-deoxy analogue was accomplished in 40% overall yield. Rather than synthesize the corresponding 2',3'-dideoxynucleoside (2) of 2,8-diaza-3- deazainosine in the same manner, i.e. deoxygenation of the 2'- deoxynucleoside, a more cost-effective route was chosen. This pathway involved reductive cleavage of the 5'-protected, 2',3'-thiocarbonate derivative to furnish a mixture of the 2'- and 3'-deoxy isomers. This mixture was not separated, but was deoxygenated by the aforementioned imidazolide method. Using this methodology, 2 was prepared in 23% overall yield from 2,8- diaza-3-deazainosine. Nucleosides 1 and 2 were evaluated for antiretroviral activity and were found to be inactive. (C) 1999 Elsevier Science Ltd.