5'-O-TERT-BUTYLDIMETHYLSILYL-2'-DEOXYINOSINE

Base Information

• Chemical Name: 5'-O-TERT-BUTYLDIMETHYLSILYL-2'-DEOXYINOSINE
• CAS No.: 260562-59-2
• Molecular Formula: C₁₆H₂₆N₄O₄Si
• Molecular Weight: 366.492
• Mol file: 260562-59-2.mol

Synonyms:1-(5-O-tert-butyldimethylsilyl-2-deoxy-β-D-erythro-pentofuranosyl)imidazo[4,5-d]pyridazin-4(5H)-one

Chemical Property of 5'-O-TERT-BUTYLDIMETHYLSILYL-2'-DEOXYINOSINE

Chemical Property:

Purity/Quality:

5?-O-tert-butyldimethylsilyl-2?-deoxyinosine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5'-O-TERT-BUTYLDIMETHYLSILYL-2'-DEOXYINOSINE

There total 2 articles about 5'-O-TERT-BUTYLDIMETHYLSILYL-2'-DEOXYINOSINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

2-deoxyinosine (890-38-0) + tert-butyldimethylsilyl chloride (18162-48-6) → 1-(5-O-tert-butyldimethylsilyl-2-deoxy-β-D-erythro-pentofuranosyl)imidazo[4,5-d]pyridazin-4(5H)-one (260562-59-2)

Guidance literature:

With 1H-imidazole; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 2h;

Reference yield: 67.0%

tert-butyldimethylsilyl chloride (18162-48-6) + 1-(2-deoxy-α,β-D-erythro-pentofuranosyl)imidazo[4,5-d]pyridazine-4(5H)-one → 1-(5-O-tert-butyldimethylsilyl-2-deoxy-α-D-erythro-pentofuranosyl)imidazo[4,5-d]pyridazin-4(5H)-one + 1-(5-O-tert-butyldimethylsilyl-2-deoxy-β-D-erythro-pentofuranosyl)imidazo[4,5-d]pyridazin-4(5H)-one (260562-59-2)

Guidance literature:

With 1H-imidazole; In N,N-dimethyl-formamide;

DOI:10.1016/S0968-0896(99)00184-4

Reference yield: 40.0%

phenylcarbonochloridothioate (1005-56-7) + 1-(5-O-tert-butyldimethylsilyl-2-deoxy-β-D-erythro-pentofuranosyl)imidazo[4,5-d]pyridazin-4(5H)-one (260562-59-2) → 1-(5-O-tert-butyldimethylsilyl-3-O-phenoxythiocarbonyl-2-deoxy-β-D-erythro-pentofuranosyl)-imidazo[4,5-d]pyridazin-4(5H)-one (260562-60-5)

Guidance literature:

With dmap; triethylamine; In acetonitrile; at 20 ℃; for 5h;

DOI:10.1016/S0968-0896(99)00184-4

upstream raw materials:

tert-butyldimethylsilyl chloride

2-deoxyinosine

Downstream raw materials:

1-(5-O-tert-butyldimethylsilyl-3-O-phenoxythiocarbonyl-2-deoxy-β-D-erythro-pentofuranosyl)-imidazo[4,5-d]pyridazin-4(5H)-one

Dideoxyinosine