- Compound comprising urea and thiourea structures and synthesis method and application of compound
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The invention relates to an organic small molecular compound comprising urea and thiourea structures in a formula I and a synthesis method and application of the compound. According to in-vitro antitumor activity tests, the compound has high antitumor act
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Paragraph 0064-0065
(2019/08/07)
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- Chemoselective reduction of isothiocyanates to thioformamides mediated by the Schwartz reagent
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Thioformamides are easily prepared-under full chemocontrol-through the partial reduction of isothiocyanates with the in situ generated Schwartz reagent. The high electrophilicity of the starting materials enables the straightforward addition of the hydride ion, thus constituting a reliable and high-yielding method for obtaining variously functionalized thioformamides. Sensitive chemical groups to the reduction conditions such as nitro, ester, alkene, azo, azide and keto groups do not interfere with the chemoselectivity of the process. Moreover, the stereochemical information embodied in the starting material is fully retained in the final products. The synthetic potential of the selected thioformamide template is also briefly discussed.
- De La Vega-Hernández, Karen,Senatore, Raffaele,Miele, Margherita,Urban, Ernst,Holzer, Wolfgang,Pace, Vittorio
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supporting information
p. 1970 - 1978
(2019/02/20)
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- Direct Conversion of Formanilides into Thioformanilides Using Solubilized Phosphorus Pentasulphide
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Direct conversion of formanilides into thioformanilides, not reported so far, has now been achieved in good to excellent yields using solubilized phosphorus pentasulphide of controlled reactivity.
- Rao, C. Someswara,Murty, V. S. N.,Tattu, P. K.
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p. 1083 - 1084
(2007/10/02)
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