26060-31-1Relevant academic research and scientific papers
Compound comprising urea and thiourea structures and synthesis method and application of compound
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Paragraph 0064-0065, (2019/08/07)
The invention relates to an organic small molecular compound comprising urea and thiourea structures in a formula I and a synthesis method and application of the compound. According to in-vitro antitumor activity tests, the compound has high antitumor act
Chemoselective reduction of isothiocyanates to thioformamides mediated by the Schwartz reagent
De La Vega-Hernández, Karen,Senatore, Raffaele,Miele, Margherita,Urban, Ernst,Holzer, Wolfgang,Pace, Vittorio
supporting information, p. 1970 - 1978 (2019/02/20)
Thioformamides are easily prepared-under full chemocontrol-through the partial reduction of isothiocyanates with the in situ generated Schwartz reagent. The high electrophilicity of the starting materials enables the straightforward addition of the hydride ion, thus constituting a reliable and high-yielding method for obtaining variously functionalized thioformamides. Sensitive chemical groups to the reduction conditions such as nitro, ester, alkene, azo, azide and keto groups do not interfere with the chemoselectivity of the process. Moreover, the stereochemical information embodied in the starting material is fully retained in the final products. The synthetic potential of the selected thioformamide template is also briefly discussed.
Direct Conversion of Formanilides into Thioformanilides Using Solubilized Phosphorus Pentasulphide
Rao, C. Someswara,Murty, V. S. N.,Tattu, P. K.
, p. 1083 - 1084 (2007/10/02)
Direct conversion of formanilides into thioformanilides, not reported so far, has now been achieved in good to excellent yields using solubilized phosphorus pentasulphide of controlled reactivity.
