- Pseudo-five-component organocatalyzed synthesis of dicyanoanillines using only malononitrile and aromatic aldehydes
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A pseudo-five-component reaction leading to efficient synthesis of dicyanoanillines was developed using only aromatic aldehydes and malononitrile as the starting reactants. Mechanistic studies suggested that a malononitrile dimer and the Knoevenagel conde
- Abaee, M. Saeed,Hatamifard, Arezo,Mojtahedi, Mohammad M.,Naderi, Soheila,Notash, Behrouz
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supporting information
(2022/01/19)
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- Discovery of Highly Potent Adenosine A1Receptor Agonists: Targeting Positron Emission Tomography Probes
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Adenosine receptor (AR) radiotracers for positron emission tomography (PET) have provided knowledge on the in vivo biodistribution of ARs in the central nervous system (CNS), which is of therapeutic interest for various neuropsychiatric disorders. Additio
- Bakhoda, Abolghasem,Eisenberg, Seth M.,Fowler, Joanna S.,Gao, Zhan-Guo,Guo, Min,Hooker, Jacob M.,Jacobson, Kenneth A.,Javdan, Cameron,Kang, Yeona,Kelleher, Andrew C.,Kim, Sung Won,Li, Yang,O'Conor, Kelly A.,Ramsey, Joseph M.,Rice, Kenner C.,Volkow, Nora D.,Yan, Xuefeng
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- The aminopyridine-3,5-dicarbonitrile core for the design of new non-nucleoside-like agonists of the human adenosine A2B receptor
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A new series of amino-3,5-dicyanopyridines (3–28) as analogues of the adenosine hA2B receptor agonist BAY60-6583 (compound 1) was synthesized. All the compounds that interact with the hA2B adenosine receptor display EC50 v
- Betti, Marco,Catarzi, Daniela,Varano, Flavia,Falsini, Matteo,Varani, Katia,Vincenzi, Fabrizio,Dal Ben, Diego,Lambertucci, Catia,Colotta, Vittoria
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p. 127 - 139
(2018/03/13)
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- Preclinical Evaluation of the First Adenosine A1 Receptor Partial Agonist Radioligand for Positron Emission Tomography Imaging
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Central adenosine A1 receptor (A1R) is implicated in pain, sleep, substance use disorders, and neurodegenerative diseases, and is an important target for pharmaceutical development. Radiotracers for A1R positron emission t
- Guo, Min,Gao, Zhan-Guo,Tyler, Ryan,Stodden, Tyler,Li, Yang,Ramsey, Joseph,Zhao, Wen-Jing,Wang, Gene-Jack,Wiers, Corinde E.,Fowler, Joanna S.,Rice, Kenner C.,Jacobson, Kenneth A.,Kim, Sung Won,Volkow, Nora D.
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p. 9966 - 9975
(2018/11/23)
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- Green one-pot synthesis of novel polysubstituted pyrazole derivatives as potential antimicrobial agents
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Various biological properties of natural and synthetic pyrazole derivatives such as anti-inflammatory, antimicrobial, neuroprotective, anticonvulsant, antidepressant and anticancer activities encouraged us to propose a new, fast, green and eco-friendly pr
- Beyzaei, Hamid,Motraghi, Zahra,Aryan, Reza,Zahedi, Mohammad Mehdi,Samzadeh-Kermani, Alireza
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p. 911 - 918
(2018/01/17)
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- NOVEL CYANOPYRIMIDINE DERIVATIVE
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The present invention relates to a novel cyanopyrimidine compound and a pharmaceutical composition which have a safe and potent adenosine A2a receptor agonistic activity.
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Page/Page column 12
(2012/02/03)
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- Substituted 2-thio-3,5-dicyano-4-aryl-6-aminopyridines and the use thereof
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This application relates to compounds of formula (I), wherein R1, R2, R3, and R4 are defined as recited in the claims, or a tautomer, salt, hydrate, or alkoxide thereof. A process for preparing such materials, p
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Page/Page column 46
(2008/06/13)
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