260967-14-4

Basic information

• Product Name: (E)-benzyl prop-1-en-1-ylcarbamate
• Synonyms: (E)-benzyl prop-1-en-1-ylcarbamate;Carbamic acid, (1E)-1-propenyl-, phenylmethyl ester
• CAS NO: 260967-14-4
• Molecular Formula: C₁₁H₁₃NO₂
• Molecular Weight: 191.22642
• EINECS: -0
• Mol File: 260967-14-4.mol

Chemical Properties

• Boiling Point: 291.7±23.0 °C(Predicted)
• Appearance: /
• Density: 1.076±0.06 g/cm3(Predicted)
• PKA: 11.65±0.46(Predicted)
• CAS DataBase Reference: (E)-benzyl prop-1-en-1-ylcarbamate(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-benzyl prop-1-en-1-ylcarbamate(260967-14-4)
• EPA Substance Registry System: (E)-benzyl prop-1-en-1-ylcarbamate(260967-14-4)

Safety Data

• Hazardous Substances Data: 260967-14-4(Hazardous Substances Data)

Usage

Uses

Used in Cosmetics and Personal Care Industry:
(E)-Benzyl prop-1-en-1-ylcarbamate is used as a fragrance ingredient in cosmetics and personal care products for its pleasant floral and sweet scent. It is commonly added to perfumes, lotions, and soaps to enhance their aroma and provide a more enjoyable user experience.
Used in Food Flavoring Industry:
In the food flavoring industry, (E)-benzyl prop-1-en-1-ylcarbamate is used as a flavoring agent to impart a sweet and floral taste to various food products. Its unique flavor profile can add depth and complexity to a wide range of culinary creations.
However, it is important to note that (E)-benzyl prop-1-en-1-ylcarbamate is also known to be a potential allergen. It can trigger allergic reactions in some individuals, particularly those with sensitive skin or respiratory systems. As a result, it is crucial to use products containing (E)-benzyl prop-1-en-1-ylcarbamate with caution and to follow proper safety guidelines to minimize the risk of adverse effects.

Upstream product

• 100-51-6 benzyl alcohol 
• 621-84-1 O-benzyl carbamate 
• 5041-33-8 N-(Benzyloxycarbonyl)allylamine 
• 20395-87-3 2-(N-benzyloxycarbonylamino)butyric acid 
• 19728-63-3 N-benzyloxycarbonyl-L-treonine 

Downstream Products

• 904822-38-4 benzyl (2R,3S)-3-ethoxycarbonyl-3-hydroxy-2-methylpropylcarbamate 
• 904822-45-3 benzyl (2S,3S)-3-ethoxycarbonyl-3-hydroxy-2-methylpropylcarbamate 
• 1332344-20-3 (2-ethyl-6-methoxy-3-methyl-1,2,3,4-tetrahydroquinolin-4-yl)carbamic acid benzyl ester 
• 1332344-19-0 (2-cyclohexyl-6-methoxy-3-methyl-1,2,3,4-tetrahydroquinolin-4-yl)carbamic acid benzyl ester 
• 1332344-21-4 (2-((benzyloxy)methyl)-6-methoxy-3-methyl-1,2,3,4-tetrahydroquinolin-4-yl)carbamic acid benzyl ester 
• 1332344-14-5 (6-methoxy-2-(3-methoxyphenyl)-3-methyl-1,2,3,4-tetrahydroquinolin-4-yl)carbamic acid benzyl ester 
• 1197815-62-5 (3-methyl-6-nitro-2-phenyl-1,2,3,4-tetrahydro-quinolin-4-yl)-carbamic acid benzyl ester 

Relevant articles and documents

Lewis Acid Catalyzed [3+2] Coupling of Quinone Monoacetals or Quinone Imine Ketals with Vinylcarbamates

A mild and concise [3+2] coupling of quinone monoacetals or quinone imine ketals with vinylcarbamates promoted by Lewis acid was realized. Various 2-carbamate-2,3-dihydrobenzofurans and 2-carbamate-indolines have been prepared in moderate to good yields.

Photoinduced Kochi Decarboxylative Elimination for the Synthesis of Enamides and Enecarbamates from N-Acyl Amino Acids

Decarboxylative elimination of easily accessible N-acyl amino acids to provide enamide and enecarbamate building blocks has been realized through the combination of an organophotoredox catalyst and copper acetate as the terminal oxidant. This operationally simple process utilizes inexpensive and readily available reagents without preactivation of the carboxylic acid. Enamides and enecarbamates are now accessible directly from N-acyl amino acids consequently improving upon the utility of Kochi's oxidative decarboxylation of carboxylic acids.

Structure-Dependent Nickel-Catalysed Transposition of N -Allylamides to E- or Z-Enamides

The nickel-catalysed transposition of a carbon-carbon double bond of N-allyl and N-homoallyl amides is described. While the transposition of acyclic amides gave very high Z-selectivity of the enamides, corresponding cyclic N-allyl amides led exclusively t

TETRAHYDROQUINOLINE DERIVATIVES AS BROMODOMAIN INHIBITORS

The present invention relates to specific novel compounds, pharmaceutical compositions containing such compounds and to their use in therapy as bromodomain inhibitors.

Nickel-Catalyzed Synthesis of Enamides and Enecarbamates via Isomerization of Allylamides and Allylcarbamates

A single-component, air-stable nickel precatalyst can catalyze the isomerization of allylamides for the synthesis of enamides. The scope of the reaction encompasses various substituted allylamides and allylcarbamates as well as homoallylamides. The reaction can be performed on a multigram-scale without specialized glove-box equipment or Schlenk techniques.

Photoredox-induced three-component Oxy-, Amino-, and Carbotrifluoromethylation of enecarbamates

A photoredox-catalzyed trifluoromethylation of enecarbamates process is reported. This pathway uses Togni's reagent as the CF3 source and follows a radical/cationic pathway. Under the optimized conditions using [Ru(bpy)3(PF6)2] as the photocatalyst, a wide range of substituted enecarbamates can readily be difunctionalized by means of various O, N, and C nucleophiles.

2,3-DISUBSTITUTED 1 -ACYL-4-AMINO-1,2,3,4-TETRAHYDROQUINOLINE DERIVATIVES AND THEIR USE AS BROMODOMAIN INHIBITORS

The present invention relates to novel compounds of formula (I), wherein R1 is C1-4alkyl; R2 is C1-4alkyl, C3-7cycloalkyl, -CH2CF3, -CH2OCH3 or heterocyclyl; R3 is C1-4alkyl, -CH2F, -CH2OH or -CH2O(O)CH3; R4 when present is as defined in claim 1; R5 when present is H, halo, hydroxy or C1-6alkoxy; A is -NH-, -O-, -S-, -SO-, -SO2-, -N(C1-4alkyl)- or -NC(O)(CH3)-; V is phenyl, heteroaromatic or pyridone any of which may be optionally substituted by 1, 2 or 3 substituents; W is CH or N; X is C or N; Y is C or N; and Z is CH or N; subject to the proviso that no more than 2 of W, X, Y and Z are N, pharmaceutical compositions containing such compounds and to their use as bromodomain inhibitors.

A stereoselective synthesis of primary (Z)-enecarbamates from α- amidoalkylphenyl sulfones

A base assisted elimination of phenylsulfinic acid from α- amidoalkylphenyl sulfones leads to the synthesis of the corresponding enecarbamates. The Z stereoisomer of the enecarbamate is preferentially formed.