26137-07-5

Basic information

• Product Name: METHYL 4-(4-BROMOPHENYL)THIOPHENE-2-CARBOXYLATE
• Synonyms: METHYL 4-(4-BROMOPHENYL)THIOPHENE-2-CARBOXYLATE;BUTTPARK 46\15-20;2-THIOPHENECARBOXYLIC ACID, 4-(4-BROMOPHENYL)-, METHYL ESTER
• CAS NO: 26137-07-5
• Molecular Formula: C₁₂H₉BrO₂S
• Molecular Weight: 297.17
• Mol File: 26137-07-5.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: METHYL 4-(4-BROMOPHENYL)THIOPHENE-2-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 4-(4-BROMOPHENYL)THIOPHENE-2-CARBOXYLATE(26137-07-5)
• EPA Substance Registry System: METHYL 4-(4-BROMOPHENYL)THIOPHENE-2-CARBOXYLATE(26137-07-5)

Safety Data

• Hazardous Substances Data: 26137-07-5(Hazardous Substances Data)

Upstream product

• 5380-42-7 thiophene-2-carboxylic acid methyl ester 
• 589-87-7 1,4-bromoiodobenzene 
• 666721-42-2 methyl 4-(4-aminophenyl)thiophene-2-carboxylate 
• 23801-14-1 2-(4-Bromophenyl)-3-(dimethylamino)allylidene(dimethyl)ammonium perchlorate 
• 2365-48-2 Methyl thioglycolate 

Downstream Products

• 766536-21-4 (S)-3-Phenyl-3-{[4-(4-pyridin-4-yl-phenyl)-thiophene-2-carbonyl]-amino}-propionic acid 
• 820224-07-5 methyl 4-[4-(pyridin-4-yl)phenyl]thiophen-2-carboxylate 

Relevant articles and documents

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A compound of formula (I) selected from: wherein: X represents oxygen or sulphur, Y represents oxygen, —NH— or —N(C1-C6)alkyl-, Ra represents hydrogen, halogen, (C1-C3)alkyl, hydroxyl or (C1-C3)alkoxy, Rb represents hydrogen, halogen or (C1-C3)alkyl, A represents phenyl, pyridyl, (C5-C6)cycloalkyl or (C5-C6)cycloalkenyl, R1 and R2 each represent a group selected from hydrogen, halogen, cyano, nitro, haloalkyl, haloalkoxy, alkyl, alkenyl, alkynyl, —OR4, —NR4R5, —S(O)nR4, —C(O)R4, —CO2R4, —O—C(O)R4, —C(O)NR4R5, —NR5—C(O)R4, —NR5—SO2R4, -T-CN, -T-OR4, -T-OCF3, -T- NR4R5, -T-S(O)nR4, -T-C(O)R4, -T-CO2R4, -T-O—C(O)R4, -T-C(O)NR4R5, -T-NR4—C(O)R5, -T-NR4—SO2R5, —R6 and -T-R6 in which n, T, R4, R5 and R6 are as defined in the description, R3 represents an —R7 or —U—R11 group in which R7 represents hydrogen, alkyl, aryl, cycloalkyl or heterocycle, U represents a linear or branched alkylene chain and R11 is defined in the description, their optical isomers or their addition salts with a pharmaceutically acceptable acid or base, and their use as inhibitor of metalloproteinase and more specifically of metalloproteinase-12.