820224-07-5Relevant academic research and scientific papers
Structure-based design and synthesis of novel non-zinc chelating MMP-12 inhibitors
Dublanchet, Anne-Claude,Ducrot, Pierre,Andrianjara, Charles,O'Gara, Margaret,Morales, Renaud,Compere, Delphine,Denis, Alexis,Blais, Stephane,Cluzeau, Philippe,Courte, Karine,Hamon, Jacques,Moreau, Francois,Prunet, Marie-Laure,Tertre, Anita
, p. 3787 - 3790 (2007/10/03)
A new class of MMP-12 inhibitors was discovered and optimized using structure-based drug design methods. Modeling studies using a known MMP-12 crystal structure identified a new interaction mode for these new MMP-12 inhibitors. Further optimization resulted in the discovery of a compound displaying nanomolar activity against MMP-12 and which was co-crystallized with MMP-12.
