- A 1 - ethyl - 2 - nitro-methylene pyrrolidine synthetic method (by machine translation)
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The invention relates to a 1 - ethyl - 2 - nitro-methylene pyrrolidine synthetic method, the synthetic method 1 - ethyl pyrrolidone (I) as raw materials, the reaction solvent is added first, then adding phosphorus oxychloride or thionyl chloride, so that the 1 - ethyl pyrrolidone (I) and phosphorus oxychloride or thionyl chloride through Vilsmeier reaction to obtain the Vilsmeier salt intermediate (II); Vilsmeier salt intermediate (II) with nitromethane and sodium methoxide methanol solution obtained by reaction of 1 - ethyl - 2 - nitro-methylene pyrrolidine (III); synthetic route thereof is: . The advantage of this invention lies in: through the synthetic method of this invention, can make the 1 - ethyl - 2 - nitro-methylene pyrrolidine with higher yield, yield can be up to 70% or more, and the synthesizing method, simple and easy to operate, is suitable for the corresponding to the industrial production. (by machine translation)
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Paragraph 0012; 0013; 0014; 0015; 0016; 0017; 0018
(2017/07/20)
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