261710-79-6

Basic information

• Product Name: 4-Thiazolecarboxaldehyde, 5-methyl-
• Synonyms: 4-Thiazolecarboxaldehyde, 5-methyl-;5-Methyl-4-thio-carbalddehyde;5-Methylthiazole-4-carbaldehyde
• CAS NO: 261710-79-6
• Molecular Formula: C₅H₅NOS
• Molecular Weight: 127.16
• Mol File: 261710-79-6.mol

Chemical Properties

• Boiling Point: 228.1±20.0 °C(Predicted)
• Appearance: /
• Density: 1.270±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 0.99±0.10(Predicted)
• CAS DataBase Reference: 4-Thiazolecarboxaldehyde, 5-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Thiazolecarboxaldehyde, 5-methyl-(261710-79-6)
• EPA Substance Registry System: 4-Thiazolecarboxaldehyde, 5-methyl-(261710-79-6)

Safety Data

• Hazardous Substances Data: 261710-79-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
4-Thiazolecarboxaldehyde, 5-methylis used as a building block for the synthesis of various pharmaceuticals due to its unique chemical structure and properties. It contributes to the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
4-Thiazolecarboxaldehyde, 5-methylis also used as an intermediate in the production of pesticides and other agrochemicals, helping to create effective solutions for pest control and crop protection.
Used in Food Industry:
4-Thiazolecarboxaldehyde, 5-methylis used as a flavoring agent in the food industry, leveraging its distinctive odor to enhance the taste and aroma of various food products.
Used in Medicinal Chemistry and Drug Development:
4-Thiazolecarboxaldehyde, 5-methylhas been studied for its potential use as an anti-fungal and anti-bacterial agent, making it a valuable compound in the field of medicinal chemistry and drug development. Its properties are being explored for the creation of new treatments and therapies to combat various infections and diseases.

Upstream product

• 61323-26-0 5-methyl-thiazole-4-carboxylic acid ethyl ester 

Relevant articles and documents

COMPOSITIONS AND METHODS OF MODULATING SHORT-CHAIN DEHYDROGENASE ACTIVITY

Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors described herein.

HETEROARYL COMPOUNDS USEFUL AS INHIBITORS OF SUMO ACTIVATING ENZYME

Disclosed are chemical entities which are compounds of formula (I); or pharmaceutically acceptable salts thereof; wherein Y, Ra, Ra', Rb, Rc, X1, X2, X3, Rd, Z1, and Z2 have the values described herein and stereochemical configurations depicted at asterisked positions indicate absolute stereochemistry. Chemical entities according to the disclosure can be useful as inhibitors of Sumo Activating Enzyme (SAE). Further provided are pharmaceutical compositions comprising a compound of the disclosure and methods of using the compositions in the treatment of proliferative, inflammatory, cardiovascular, and neurodegenerative diseases or disorders.

HIV protease inhibitors

The present invention relates to novel dihydropyrones with tethered heterocycles having improved pharmacologic properties which potently inhibit the HIV aspartyl protease blocking HIV infectivity. The dihydropyrones are useful in the development of therapies for the treatment of viral infections and diseases, including AIDS. The present invention is also directed to methods of synthesis of the dihydropyrones and intermediates useful in the preparation of the final compounds.

4-Hydroxy-5,6-dihydropyrones as inhibitors of HIV protease: The effect of heterocyclic substituents at C-6 on antiviral potency and pharmacokinetic parameters

Due largely to the emergence of multi-drug-resistant HIV strains, the development of new HIV protease inhibitors remains a high priority for the pharmaceutical industry. Toward this end, we previously identified a 4-hydroxy-5,6-dihydropyrone lead compound