61323-26-0

Basic information

• Product Name: 5-METHYL-THIAZOLE-4-CARBOXYLIC ACID
• Synonyms: 5-METHYL-THIAZOLE-4-CARBOXYLIC ACID;4-Thiazolecarboxylicacid, 5-methyl-, ethyl ester;5-Methyl-thiazole-4-carboxylic acid ethyl ester;ETHYL 5-METHYLTHIAZOLE-4-CARBOXYLATE;4-Ethoxycarbonyl-5-methylthiazole;Ethyl 5-methyl-4-thiazolecarboxylate;ethyl 5-Methyl-1,3-thiazole-4-carboxylate;Ethyl 5-Methylthiazloe-4-carboxylate
• CAS NO: 61323-26-0
• Molecular Formula: C₇H₉NO₂S
• Molecular Weight: 143.16
• Mol File: 61323-26-0.mol

Chemical Properties

• Melting Point: 90-91℃
• Boiling Point: 239℃
• Flash Point: 98℃
• Appearance: /
• Density: 1.198
• Storage Temp.: 2-8°C
• PKA: 0.86±0.10(Predicted)
• CAS DataBase Reference: 5-METHYL-THIAZOLE-4-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 5-METHYL-THIAZOLE-4-CARBOXYLIC ACID(61323-26-0)
• EPA Substance Registry System: 5-METHYL-THIAZOLE-4-CARBOXYLIC ACID(61323-26-0)

Safety Data

• Hazardous Substances Data: 61323-26-0(Hazardous Substances Data)

Usage

Chemical Properties

pale yellow solid

InChI:InChI=1/C7H9NO2S/c1-3-10-7(9)6-5(2)11-4-8-6/h4H,3H2,1-2H3

Upstream product

• 926-67-0 O-Ethyl thioacetate 
• 2999-46-4 Ethyl isocyanoacetate 
• 72054-60-5 2-amino-5-methylthiazole-4-carboxylic acid ethyl ester 
• 507-09-5 tiolacetic acid 
• 64-17-5 ethanol 
• 120237-76-5 5-methylthiazole-4-carboxylic acid 

Downstream Products

• 261710-79-6 5-methyl-thiazole-4-carbaldehyde 

Relevant articles and documents

2-(1H-INDOLE-3-CARBONYL)-THIAZOLE-4-CARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS ARYL HYDROCARBON RECEPTOR (AHR) AGONISTS FOR THE TREATMENT OF E.G. ANGIOGENESIS IMPLICATED OR INFLAMMATORY DISORDERS

2-(1H-lndole-3-carbonyl)-thiazole-4-carboxamide derivatives and the corresponding imidazole, oxazole and thiophene derivatives and related compounds as aryl hydrocarbon receptor (AHR) agonists for the treatment of angiogenesis implicated disorders, such as e.g. retinopathy, psoriasis, rheumatoid arthritis, obesity and cancer, or inflammatory disorders. The present description discloses the synthesis and characterisation of exemplary compounds as well as pharmacological data thereof (e.g. pages 27 to 32 and 59 to 219; examples 1 to 8; compounds 1-1 to 1-97; tables 1-a, 2 and 3).

One-pot four-component synthesis of polysubstituted thiazoles via cascade Ugi/Wittig cyclization starting from odorless Isocyano(triphenylphosphoranylidene)-acetates

A new one-pot four-component preparation of polysubstituted thiazoles by a cascade Ugi/Wittig cyclization has been developed. The four-component reactions of the odorless isocyano(triphenylphosphoranylidene)acetates 1, aldehydes 2, amines 3 and thiocarboxylic acids 4 produced 2,4,5-trisubstituted thiazoles 5 in moderate to good yields in the presence of triethylamine. The two-component reactions between isocyano(triphenylphosphoranylidene)acetates 1 and thiocarboxylic acids 4 in the presence of triethylamine provided the corresponding 4,5-disubstituted thiazoles 6 in good yields as well.

TETRAHYDROCYCLOPENTA[b] INDOLE COMPOUNDS AS ANDROGEN RECEPTOR MODULATORS

The present invention provides a compound of the formula: Formula (I) or a pharmaceutically acceptable salt thereof; pharmaceutical compositions comprising a compound of Formula (I) in combination with a suitable carrier, diluent, or excipient; and methods for treating physiological disorders, particularly reduced bones mass, osteoporosis, osteopenia, or reduced muscle mass or strength, comprising administering a compound of Formula (I), or a pharmaceutically acceptable salt thereof. X-17142.

The Preparation of Thiazole-4- and -5-carboxylates, and an Infrared Study of their Rotational Isomers

Convenient general procedures have been developed for preparing series of thiazole-4- and -5-carboxylates containing alkyl and halogeno substituents.While both series of esters show i.r. carbonyl doublets caused by rotational isomerism, the more intense absorptions of the 4-carboxylates are the lower wavenumber components, whereas those of the 5-carboxylates are the higher wavenumber components.In both series the stronger bands arise from the thermochemically more stable forms; identification of these forms as the carbonyl O,S-syn-s-trans rotamers is more certain with the 4-carboxylates than with the 5-carboxylates.

Novel process for the preparation of thiazoles

A novel process disclosed for the preparation of substituted thiazoles. The process utilizes a loweralkyl thioformate or a substituted loweralkyl thioformate and an isocyanoacetonitrile or an isocyanoloweralkanoate in the presence of a base.