61323-26-0

Basic information

• Product Name: 5-METHYL-THIAZOLE-4-CARBOXYLIC ACID
• Synonyms: 5-METHYL-THIAZOLE-4-CARBOXYLIC ACID;4-Thiazolecarboxylicacid, 5-methyl-, ethyl ester;5-Methyl-thiazole-4-carboxylic acid ethyl ester;ETHYL 5-METHYLTHIAZOLE-4-CARBOXYLATE;4-Ethoxycarbonyl-5-methylthiazole;Ethyl 5-methyl-4-thiazolecarboxylate;ethyl 5-Methyl-1,3-thiazole-4-carboxylate;Ethyl 5-Methylthiazloe-4-carboxylate
• CAS NO: 61323-26-0
• Molecular Formula: C₇H₉NO₂S
• Molecular Weight: 143.16
• Mol File: 61323-26-0.mol
• Article Data: 5

Chemical Properties

• Melting Point: 90-91℃
• Boiling Point: 239℃
• Flash Point: 98℃
• Appearance: /
• Density: 1.198
• Storage Temp.: 2-8°C
• PKA: 0.86±0.10(Predicted)
• CAS DataBase Reference: 5-METHYL-THIAZOLE-4-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 5-METHYL-THIAZOLE-4-CARBOXYLIC ACID(61323-26-0)
• EPA Substance Registry System: 5-METHYL-THIAZOLE-4-CARBOXYLIC ACID(61323-26-0)

Safety Data

• Hazardous Substances Data: 61323-26-0(Hazardous Substances Data)

Usage

Chemical Properties

pale yellow solid

InChI:InChI=1/C7H9NO2S/c1-3-10-7(9)6-5(2)11-4-8-6/h4H,3H2,1-2H3

Upstream product

• 926-67-0 O-Ethyl thioacetate 
• 2999-46-4 Ethyl isocyanoacetate 
• 72054-60-5 2-amino-5-methylthiazole-4-carboxylic acid ethyl ester 
• 507-09-5 tiolacetic acid 
• 64-17-5 ethanol 
• 120237-76-5 5-methylthiazole-4-carboxylic acid 

Downstream Products

• 261710-79-6 5-methyl-thiazole-4-carbaldehyde 

Relevant articles and documents

2-(1H-INDOLE-3-CARBONYL)-THIAZOLE-4-CARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS ARYL HYDROCARBON RECEPTOR (AHR) AGONISTS FOR THE TREATMENT OF E.G. ANGIOGENESIS IMPLICATED OR INFLAMMATORY DISORDERS

2-(1H-lndole-3-carbonyl)-thiazole-4-carboxamide derivatives and the corresponding imidazole, oxazole and thiophene derivatives and related compounds as aryl hydrocarbon receptor (AHR) agonists for the treatment of angiogenesis implicated disorders, such as e.g. retinopathy, psoriasis, rheumatoid arthritis, obesity and cancer, or inflammatory disorders. The present description discloses the synthesis and characterisation of exemplary compounds as well as pharmacological data thereof (e.g. pages 27 to 32 and 59 to 219; examples 1 to 8; compounds 1-1 to 1-97; tables 1-a, 2 and 3).

TETRAHYDROCYCLOPENTA[b] INDOLE COMPOUNDS AS ANDROGEN RECEPTOR MODULATORS

The present invention provides a compound of the formula: Formula (I) or a pharmaceutically acceptable salt thereof; pharmaceutical compositions comprising a compound of Formula (I) in combination with a suitable carrier, diluent, or excipient; and methods for treating physiological disorders, particularly reduced bones mass, osteoporosis, osteopenia, or reduced muscle mass or strength, comprising administering a compound of Formula (I), or a pharmaceutically acceptable salt thereof. X-17142.

Novel process for the preparation of thiazoles

A novel process disclosed for the preparation of substituted thiazoles. The process utilizes a loweralkyl thioformate or a substituted loweralkyl thioformate and an isocyanoacetonitrile or an isocyanoloweralkanoate in the presence of a base.