261762-81-6 Usage
Uses
Used in Pharmaceutical Industry:
6-Chloro-2-fluoro-3-methylbenzoyl chloride is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique structure allows for the development of new drugs with specific therapeutic properties, contributing to advancements in medicine.
Used in Agrochemical Industry:
In the agrochemical sector, 6-chloro-2-fluoro-3-methylbenzoyl chloride serves as an essential building block for the creation of novel agrochemicals. Its incorporation into these compounds can enhance their effectiveness in crop protection and pest management, thereby supporting sustainable agriculture.
Used in Organic Synthesis:
6-Chloro-2-fluoro-3-methylbenzoyl chloride is utilized as a versatile reagent in organic synthesis, enabling the production of a wide range of organic compounds. Its unique functional groups facilitate various chemical reactions, making it a valuable tool for chemists in the synthesis of complex organic molecules.
Used in Chemical Research:
As a derivative of benzoyl chloride, 6-chloro-2-fluoro-3-methylbenzoyl chloride is employed in chemical research to explore its properties and potential applications. Its unique structure allows researchers to investigate new reaction pathways and mechanisms, contributing to the broader understanding of organic chemistry.
Check Digit Verification of cas no
The CAS Registry Mumber 261762-81-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,6,1,7,6 and 2 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 261762-81:
(8*2)+(7*6)+(6*1)+(5*7)+(4*6)+(3*2)+(2*8)+(1*1)=146
146 % 10 = 6
So 261762-81-6 is a valid CAS Registry Number.
InChI:InChI=1/C8H5Cl2FO/c1-4-2-3-5(9)6(7(4)11)8(10)12/h2-3H,1H3
261762-81-6Relevant articles and documents
Structure-Based Optimization of a Small Molecule Antagonist of the Interaction between WD Repeat-Containing Protein 5 (WDR5) and Mixed-Lineage Leukemia 1 (MLL1)
Getlik, Matth?us,Smil, David,Zepeda-Velázquez, Carlos,Bolshan, Yuri,Poda, Gennady,Wu, Hong,Dong, Aiping,Kuznetsova, Ekaterina,Marcellus, Richard,Senisterra, Guillermo,Dombrovski, Ludmila,Hajian, Taraneh,Kiyota, Taira,Schapira, Matthieu,Arrowsmith, Cheryl H.,Brown, Peter J.,Vedadi, Masoud,Al-Awar, Rima
supporting information, p. 2478 - 2496 (2016/04/10)
WD repeat-containing protein 5 (WDR5) is an important component of the multiprotein complex essential for activating mixed-lineage leukemia 1 (MLL1). Rearrangement of the MLL1 gene is associated with onset and progression of acute myeloid and lymphoblastic leukemias, and targeting the WDR5-MLL1 interaction may result in new cancer therapeutics. Our previous work showed that binding of small molecule ligands to WDR5 can modulate its interaction with MLL1, suppressing MLL1 methyltransferase activity. Initial structure-activity relationship studies identified N-(2-(4-methylpiperazin-1-yl)-5-substituted-phenyl) benzamides as potent and selective antagonists of this protein-protein interaction. Guided by crystal structure data and supported by in silico library design, we optimized the scaffold by varying the C-1 benzamide and C-5 substituents. This allowed us to develop the first highly potent (Kdisp 100 nM) small molecule antagonists of the WDR5-MLL1 interaction and demonstrate that N-(4-(4-methylpiperazin-1-yl)-3′-(morpholinomethyl)-[1,1′-biphenyl]-3-yl)-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridine-3-carboxamide 16d (OICR-9429) is a potent and selective chemical probe suitable to help dissect the biological role of WDR5.
