261896-39-3

Basic information

• Product Name: (3R,4R)-4-ISOBUTYLPYRROLIDINE-3-CARBOXYLIC ACID
• Synonyms: (3R,4R)-4-ISOBUTYLPYRROLIDINE-3-CARBOXYLIC ACID
• CAS NO: 261896-39-3
• Molecular Formula: C9H17NO2
• Molecular Weight: 171.24
• Mol File: 261896-39-3.mol

Chemical Properties

• Boiling Point: 286.863°C at 760 mmHg
• Flash Point: 127.29°C
• Appearance: /
• Density: 1.02g/cm³
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.465
• CAS DataBase Reference: (3R,4R)-4-ISOBUTYLPYRROLIDINE-3-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: (3R,4R)-4-ISOBUTYLPYRROLIDINE-3-CARBOXYLIC ACID(261896-39-3)
• EPA Substance Registry System: (3R,4R)-4-ISOBUTYLPYRROLIDINE-3-CARBOXYLIC ACID(261896-39-3)

Safety Data

• Hazardous Substances Data: 261896-39-3(Hazardous Substances Data)

Usage

Uses

Used in Medicinal Chemistry:
(3R,4R)-4-Isobutylpyrrolidine-3-carboxylic acid is used as a chiral building block for the synthesis of pharmaceuticals, leveraging its unique stereochemistry to create enantiomerically pure compounds with specific biological activities.
Used in Biochemistry:
In biochemistry, (3R,4R)-4-Isobutylpyrrolidine-3-carboxylic acid serves as a potential ligand or inhibitor, interacting with biological targets such as enzymes or receptors due to its distinct functional groups and stereochemistry.
Used in Pharmaceutical Research:
(3R,4R)-4-Isobutylpyrrolidine-3-carboxylic acid is utilized as a drug candidate in pharmaceutical research, where its biological properties are explored for therapeutic applications, potentially leading to the development of new medications.
Used in Drug Synthesis:
(3R,4R)-4-Isobutylpyrrolidine-3-carboxylic acid is employed as an intermediate in the synthesis of complex drug molecules, taking advantage of its reactive functional groups and chiral centers to construct diverse pharmaceutical agents.

InChI:InChI=1/C9H17NO2/c1-6(2)3-7-4-10-5-8(7)9(11)12/h6-8,10H,3-5H2,1-2H3,(H,11,12)/t7-,8-/m0/s1

Upstream product

• 261896-48-4 1-benzyl-4-(S)-isobutylpyrrolidine-3-(S)-carboxylic acid 
• 261896-45-1 1-benzyl-4-(R)-isobutylpyrrolidine-3-(R)-carboxylic acid 
• 81530-29-2 (E)-5-methylhex-2-enoic acid chloride 
• 41653-96-7 (E)-5-methyl-2-hexenoic acid 
• 65236-42-2 5-methyl-hex-2-ynoic acid ethyl ester 
• 90701-59-0 1,1-Dibromo-4-methyl-1-pentene 
• 79918-80-2 (Z)-5-methyl-hex-2-enoic acid ethyl ester 
• 590-86-3 isovaleraldehyde 
• 261896-43-9 3-[(E)-3-isobutylpropenoyl]-4-(S)-phenyl-2-oxazolidinone 
• 261896-46-2 (R,E)-3-(5-methylhex-2-enoyl)-4-phenyl-1,3-oxazolidine-2-one 
• 261896-44-0 1-benzyl-4-(R)-isobutyl-3-(R)-[4'-(S)-phenyl-2'-oxazolidinon-3'-yl]carbonyl pyrrolidine 
• 261896-47-3 1-benzyl-4-(S)-isobutyl-3-(S)-[4'-(R)-phenyl-2'-oxazolidinon-3'-yl]carbonyl pyrrolidine 
• 1009643-84-8 (3S,4S)-4-isobutylpyrrolidine-1,3-dicarboxylic acid 1-benzyl ester 3-methyl ester 

Relevant articles and documents

Highly efficient catalytic system for enantioselective Michael addition of aldehydes to nitroalkenes in water

(Chemical Equation Presented) Organocatalysis: A highly effective catalytic procedure for the Michael addition of aldehydes to nitroalkenes is achieved by combining the excellent asymmetric induction ability of o-TMS-protected diphenylprolinol compounds, the quick formation of enamines in the presence of benzoic acid, and the highly concentrated organic phase in water (see scheme; TMS=trimethylsilyl).

Branched alkyl pyrrolidine-3-carboxylic acids

Branched alkyl pyrrolidines of formula (I) are disclosed and are useful as agents in the treatment of epilepsy, faintness attacks, hypokinesia, cranial disorders, neurodegenerative disorders, depression, anxiety, panic, pain, and neuropatnological disorders. Processes for the preparation and intermediates useful in the preparation are also disclosed.