261896-46-2

Basic information

• Product Name: (R,E)-3-(5-methylhex-2-enoyl)-4-phenyl-1,3-oxazolidine-2-one
• Synonyms: (R,E)-3-(5-methylhex-2-enoyl)-4-phenyl-1,3-oxazolidine-2-one
• CAS NO: 261896-46-2
• Molecular Weight: 273.332
• Mol File: 261896-46-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (R,E)-3-(5-methylhex-2-enoyl)-4-phenyl-1,3-oxazolidine-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (R,E)-3-(5-methylhex-2-enoyl)-4-phenyl-1,3-oxazolidine-2-one(261896-46-2)
• EPA Substance Registry System: (R,E)-3-(5-methylhex-2-enoyl)-4-phenyl-1,3-oxazolidine-2-one(261896-46-2)

Safety Data

• Hazardous Substances Data: 261896-46-2(Hazardous Substances Data)

Upstream product

• 41653-96-7 (E)-5-methyl-2-hexenoic acid 
• 90319-52-1 (4R)-phenyl-2-oxazolidinone 
• 34993-63-0 ethyl (E)-5-methylhex-2-enoate 
• 590-86-3 isovaleraldehyde 
• 81530-29-2 (E)-5-methylhex-2-enoic acid chloride 

Downstream Products

• 261896-47-3 1-benzyl-4-(S)-isobutyl-3-(S)-[4'-(R)-phenyl-2'-oxazolidinon-3'-yl]carbonyl pyrrolidine 
• 1531586-72-7 (S)-4-methyl-2-(2-oxo-2-((R)-2-oxo-4-phenyloxazolidin-3-yl)ethyl)pentanenitrile 
• 1531586-73-8 (R)-4-methyl-2-(2-oxo-2-((R)-2-oxo-4-phenyloxazolidin-3-yl)ethyl)pentanenitrile 
• 261896-48-4 1-benzyl-4-(S)-isobutylpyrrolidine-3-(S)-carboxylic acid 
• 261896-39-3 (3S,4S)-4-(2'-methylprop-1'-yl)-3-pyrrolidine carboxylic acid 

Relevant articles and documents

Diasteroselective conjugate addition of diethylaluminum cyanide to a conjugated N -enoyl system: An alternative synthesis of (S)-pregabalin

We have explored in this work the conjugate addition of diethylaluminum cyanide (Nagata's reagent) to an N-enoyl system bearing the (R)-4-phenyl-2- oxazolidinone chiral auxiliary. Since this method provided a practical synthesis of γ-amino acids, we report the conjugate addition of diethylaluminum cyanide as the key step in the synthesis of (S)-pregabalin 1 in a five-step sequence of reactions from commercially available starting materials.