- Synthesis and evaluation of the antimicrobial activity of Dodecyl trimethyl ammonium and N-(N, N-Dimethylamino) propyl glucosylamine
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In this study Dodecyl trimethyl ammonium sulphate (DTA) was obtained through quaternization reaction between dodecylamine and dimethyl sulfate (yield: 51.5%) while Dimethylamino propyl glucosylamine (DAPGA) was successively synthesized from D-glucose and 3-Dimethylamino propylamine (yield: 93.6%). Both compounds were analyzed through NMR spectroscopy. Evaluation of their biological activity against Salmonella Typhimurium, Staphylococcus aureus and Fusarium oxysporum cubens indicated that at a concentration greater than 0.001 10- 4 mole mL -1, DTA significantly inhibited growth of Salmonella Typhimurium and Staphylococcus aureus while DAPGA was not effective. Furthermore, these two compounds showed a pronounced antifungal activity against a toxicogen fungal, Fusarium oxysporum cubens.
- Muhizi, Thoneste
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- Alkylation of ammonium salts catalyzed by imidazolium-based ionic liquid catalysts
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Quaternary ammonium salts were synthesized from ammonium salts and dialkyl carbonates over imidazolium ionic liquid catalysts. The reaction gave almost stoichiometric amounts of the quaternary ammonium salts for halides and nitrates. It was found that the electron-donating property of the alkyl moieties of ammonium cations, the electrophilic nature of the alkyl group of the carbonate, the acidity of the acid that the anion of the ammonium salt corresponds to, and the steric hindrance of the ammonium salts and the dialkyl carbonates are the key factors that influence the yields of quaternary ammonium salts. Strong electron-donating alkyl groups on the nitrogen atom of the ammonium salt, electron-withdrawing groups on the methylene carbon of dialkyl carbonate, and weaker steric hindrance of the starting ammonium salts and dialkyl carbonates favor the alkylation reaction of ammonium salts.
- Zheng, Zhuo Qun,Wang, Jie,Wu, Ting Hua,Zhou, Xiao Ping
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p. 1095 - 1101
(2008/03/27)
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- The synthesis of quaternary ammonium salts from ammonium salts and dialkyl carbonate
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Quaternary ammonium salts were synthesized from ammonium salts and dialkyl carbonates over an ionic liquid catalyst 1-ethyl-3-methylimidazolium bromide. The Royal Society of Chemistry 2006.
- Zheng, Zhuoqun,Wu, Tinghua,Zhou, Xiaoping
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p. 1864 - 1865
(2008/03/14)
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