2644-94-2

Basic information

• Product Name: 1-BENZYL-3,5-DIMETHYL-1H-PYRAZOLE-4-CARBALDEHYDE
• Synonyms: 1H-Pyrazole-4-carboxaldehyde,3,5-diMethyl-1-(phenylMethyl)-
• CAS NO: 2644-94-2
• Molecular Formula: C₁₃H₁₄N₂O
• Molecular Weight: 214.27
• Mol File: 2644-94-2.mol

Chemical Properties

• Boiling Point: 376.7 °C at 760 mmHg
• Flash Point: 181.6 °C
• Appearance: /
• Density: 1.09 g/cm³
• Vapor Pressure: 7.13E-06mmHg at 25°C
• Refractive Index: 1.576
• CAS DataBase Reference: 1-BENZYL-3,5-DIMETHYL-1H-PYRAZOLE-4-CARBALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-BENZYL-3,5-DIMETHYL-1H-PYRAZOLE-4-CARBALDEHYDE(2644-94-2)
• EPA Substance Registry System: 1-BENZYL-3,5-DIMETHYL-1H-PYRAZOLE-4-CARBALDEHYDE(2644-94-2)

Safety Data

• Hazardous Substances Data: 2644-94-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
1-Benzyl-3,5-dimethyl-1H-pyrazole-4-carbaldehyde is used as an intermediate in the synthesis of pharmaceuticals and organic compounds. Its ability to interact with biological molecules and exhibit pharmacological activities makes it a promising candidate for the development of new drugs and medicinal compounds.
Used in Medicinal Chemistry:
1-Benzyl-3,5-dimethyl-1H-pyrazole-4-carbaldehyde is used as a building block in medicinal chemistry for the development of new drugs and biologically active compounds. Its unique structure allows for the creation of compounds with specific properties and functions that can be applied in various therapeutic areas.
Used in Industrial Applications:
1-Benzyl-3,5-dimethyl-1H-pyrazole-4-carbaldehyde has potential applications in the synthesis of materials with specific properties and functions in various industrial applications. Its unique structure and properties make it a valuable component in the development of innovative materials for different industries.

InChI:InChI=1/C13H14N2O/c1-10-13(9-16)11(2)15(14-10)8-12-6-4-3-5-7-12/h3-7,9H,8H2,1-2H3

Upstream product

• 1134-81-2 1-benzyl-3,5-dimethyl-1H-pyrazole 
• 20570-96-1 benzylhydrazine dihydrochloride 
• 123-54-6 acetylacetone 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 2764-61-6 4-(1-benzyl-3,5-dimethyl-1H-pyrazol-4-ylmethylene)-2-phenyl-4H-oxazol-5-one 
• 1303527-00-5 2,2'-{[(1-benzyl-3,5-dimethyl-1H-pyrazol-4-yl)methanediyl]di(sulfanediyl)}diethanol hydrochloride 
• 1356914-75-4 C₁₅H₁₈N₂OS 
• 1356914-70-9 C₁₇H₂₂N₂OS₂ 
• 1369592-25-5 4-(1,3-diselenan-2-yl)-3,5-dimethyl-1-prop-2-en-1H-pyrazole 
• 1303644-24-7 2,2'-{[(1-benzyl-3,5-dimethyl-1H-pyrazol-4-yl)methanediyl]di(sulfanediyl)}diethanol 
• 1367597-40-7 1-benzyl-3,5-dimethyl-4-(1,3-oxathiolan-2-yl)-1H-pyrazole hydrochloride 
• 6569-34-2 1,2-diselenacyclopentane 

Relevant articles and documents

2-(pyrazol-4-yl)-1,3-oxaselenolanes from pyrazole carbaldehydes and 2-selanyl-1-ethanol

Pyrazole carbaldehydes react with 2-selanyl-1-ethanol at room temperature in the presence of trimethylchlorosilane followed by treatment C with triethyl amine to afford the corresponding 2-(pyrazol-4-yl)-1,3-oxaselenolanes. The structure of the novel compounds was confirmed by IR, 13 C, 1 H, 15N, and 77 Se NMR spectroscopy.this article online at wileyonlinelibrary.com.

Selenoacetalyzation of 4-formylpyrazoles in the presence of trimethylchlorosilane

The reaction of 3,5-dimethyl-4-formylpyrazoles, bearing various substituents at N-1 atom, with propane-1,3-diselenol and 2-hydroxypropane-1,3- diselenol in the presence of Cyrillic capital letter teCyrillic capital letter emSCl proceeds without heating to

Fragmentation of pyrazolecarbaldehyde thio- and dithioacetals under electron impact and chemical ionization

The mass spectra of 1-substituted 3,5-dimethyl-1H-pyrazole-4-carbaldehyde bis(2-hydroxyethyl) dithioacetals and thioacetals were studied for the first time. The main fragmentation pathways of their molecular ions generated under electron impact and chemic

Synthesis and reactions of pyrazole-4-carbaldehydes

1-, 3-, and 5-Alkylpyrazoles, as well as linearly bridged bis-pyrazoles, were converted into the corresponding 4-formyl derivatives by Vilsmeier-Haak reaction both under standard conditions and under microwave activation in DMF over a period of 10 min. 1,1'-(Hexane-1,6-diyl)bis(3,5-dimethyl-1H-pyrazole) and 1,1'-(benzene-1,4-diyldimethylene)bis(3,5-dimethyl-1H-pyrazole) gave rise to 4-formyl derivatives at both pyrazole rings. 5-Chloro-1,3-dialkyl-1H-pyrazoles failed to undergo formylation according to Vilsmeier-Haak or under microwave activation. 1,1'-Bridged bis-3,5-dimethyl-1H-pyrazoles reacted with 2-sulfanylethanol on heating in the presence of chloro(trimethyl)silane to give the corresponding bridgedbis-4-(1,4,6-oxadithiocan-5-yl)-1H-pyrazoles.

2-[4-(PYRAZOL-4-YLALKYL)PIPERAZIN-1-YL]-3-PHENYL PYRAZINES AND PYRIDINES AND 3-[4-(PYRAZOL-4-YLALKYL)PIPERAZIN-1-YL]-2-PHENYL PYRIDINES AS 5-HT7 RECEPTOR ANTAGONISTS

The present invention provides selective 5-HT7 receptor antagonist compounds of Formula I and their use in the treatment of migraine, persistent pain, and anxiety: where A and B are each independently C(H)= or N=, provided that at least one of A and B is -N=, n is 1-3, m is 0-3, and R14 are as defined herein.