2644-94-2Relevant articles and documents
2-(pyrazol-4-yl)-1,3-oxaselenolanes from pyrazole carbaldehydes and 2-selanyl-1-ethanol
Papernaya, Lyubov K.,Shatrova, Alexandra A.,Levanova, Ekaterina P.,Albanov, Alexandr I.,Klyba, Lyudmila V.,Rudyakova, Elena V.,Levkovskaya, Galina G.
, p. 5 - 11 (2015/03/03)
Pyrazole carbaldehydes react with 2-selanyl-1-ethanol at room temperature in the presence of trimethylchlorosilane followed by treatment C with triethyl amine to afford the corresponding 2-(pyrazol-4-yl)-1,3-oxaselenolanes. The structure of the novel compounds was confirmed by IR, 13 C, 1 H, 15N, and 77 Se NMR spectroscopy.this article online at wileyonlinelibrary.com.
Selenoacetalyzation of 4-formylpyrazoles in the presence of trimethylchlorosilane
Papernaya, Lyubov K.,Shatrova, Alexandra A.,Levanova, Ekaterina P.,Albanov, Alexandr I.,Klyba, Lyudmila V.,Rudyakova, Elena V.,Levkovskaya, Galina G.
, p. 466 - 475 (2013/12/04)
The reaction of 3,5-dimethyl-4-formylpyrazoles, bearing various substituents at N-1 atom, with propane-1,3-diselenol and 2-hydroxypropane-1,3- diselenol in the presence of Cyrillic capital letter teCyrillic capital letter emSCl proceeds without heating to
Fragmentation of pyrazolecarbaldehyde thio- and dithioacetals under electron impact and chemical ionization
Klyba,Papernaya,Sanzheeva,Shatrova,Rudyakova,Levkovskaya
body text, p. 1851 - 1858 (2012/03/11)
The mass spectra of 1-substituted 3,5-dimethyl-1H-pyrazole-4-carbaldehyde bis(2-hydroxyethyl) dithioacetals and thioacetals were studied for the first time. The main fragmentation pathways of their molecular ions generated under electron impact and chemic
Synthesis and reactions of pyrazole-4-carbaldehydes
Rudyakova,Savosik,Papernaya,Albanov,Evstaf'eva,Levkovskaya
experimental part, p. 1040 - 1044 (2011/02/25)
1-, 3-, and 5-Alkylpyrazoles, as well as linearly bridged bis-pyrazoles, were converted into the corresponding 4-formyl derivatives by Vilsmeier-Haak reaction both under standard conditions and under microwave activation in DMF over a period of 10 min. 1,1'-(Hexane-1,6-diyl)bis(3,5-dimethyl-1H-pyrazole) and 1,1'-(benzene-1,4-diyldimethylene)bis(3,5-dimethyl-1H-pyrazole) gave rise to 4-formyl derivatives at both pyrazole rings. 5-Chloro-1,3-dialkyl-1H-pyrazoles failed to undergo formylation according to Vilsmeier-Haak or under microwave activation. 1,1'-Bridged bis-3,5-dimethyl-1H-pyrazoles reacted with 2-sulfanylethanol on heating in the presence of chloro(trimethyl)silane to give the corresponding bridgedbis-4-(1,4,6-oxadithiocan-5-yl)-1H-pyrazoles.
2-[4-(PYRAZOL-4-YLALKYL)PIPERAZIN-1-YL]-3-PHENYL PYRAZINES AND PYRIDINES AND 3-[4-(PYRAZOL-4-YLALKYL)PIPERAZIN-1-YL]-2-PHENYL PYRIDINES AS 5-HT7 RECEPTOR ANTAGONISTS
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, (2009/01/20)
The present invention provides selective 5-HT7 receptor antagonist compounds of Formula I and their use in the treatment of migraine, persistent pain, and anxiety: where A and B are each independently C(H)= or N=, provided that at least one of A and B is -N=, n is 1-3, m is 0-3, and R14 are as defined herein.