20570-96-1

Basic information

• Product Name: BENZYLHYDRAZINE DIHYDROCHLORIDE
• Synonyms: BENZYL HYDRAZINE DI HCL;BENZYLHYDRAZINE DIHYDROCHLORIDE;benzyl-hydrazindihydrochloride;Benzylhydrazine2HCl;Hydrazine, benzyl, dihydrochloride.;BZHDH;Benzylhydrazine dihydrochloride,97%;BENZYLHYDRAZINE DIHY
• CAS NO: 20570-96-1
• Molecular Formula: C₇H₁₀N₂*ClH
• Molecular Weight: 195.09
• EINECS: 243-887-1
• Product Categories: Hydrazines;Nitrogen Compounds;Organic Building Blocks;Pharmaceutical intermediate
• Mol File: 20570-96-1.mol
• Article Data: 6

Chemical Properties

• Melting Point: 143-145 °C (dec.)(lit.)
• Boiling Point: 265.4 °C at 760 mmHg
• Flash Point: 132 °C
• Appearance: Slightly yellow to beige/Powder
• Density: 0.628g/cm3 at 23℃
• Storage Temp.: Inert atmosphere,Room Temperature
• Water Solubility: Insoluble in water.
• BRN: 3688990
• CAS DataBase Reference: BENZYLHYDRAZINE DIHYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: BENZYLHYDRAZINE DIHYDROCHLORIDE(20570-96-1)
• EPA Substance Registry System: BENZYLHYDRAZINE DIHYDROCHLORIDE(20570-96-1)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36-37/39
• RIDADR: UN 2811 6.1/PG 3
• WGK Germany: 3
• RTECS: MU8540000
• F: 10
• TSCA: Yes
• HazardClass: 6.1
• PackingGroup: Ⅲ
• Hazardous Substances Data: 20570-96-1(Hazardous Substances Data)

Usage

Description

BENZYLHYDRAZINE DIHYDROCHLORIDE is an organic compound that serves as a crucial raw material and intermediate in various chemical industries. It is known for its significant role in organic synthesis, pharmaceuticals, agrochemicals, and dyestuff fields due to its versatile chemical properties and reactivity.

Uses

Used in Organic Synthesis:
BENZYLHYDRAZINE DIHYDROCHLORIDE is used as a key intermediate for the synthesis of various organic compounds. Its ability to form a wide range of chemical bonds makes it a valuable component in creating complex organic molecules.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, BENZYLHYDRAZINE DIHYDROCHLORIDE is used as a building block for the development of new drugs. Its unique chemical structure allows it to be incorporated into various drug molecules, potentially leading to the discovery of novel therapeutic agents.
Used in Agrochemicals:
BENZYLHYDRAZINE DIHYDROCHLORIDE is utilized as an essential component in the production of agrochemicals, such as pesticides and fertilizers. Its role in these products helps improve their effectiveness and efficiency in agricultural applications.
Used in Dyestuff Industry:
In the dyestuff industry, BENZYLHYDRAZINE DIHYDROCHLORIDE is employed as a vital intermediate for the synthesis of various dyes and pigments. Its contribution to the dye manufacturing process results in a wide range of colors and improved dye performance.

Safety Profile

Poison by intraperitoneal route.Questionable carcinogen with experimental neoplastigenicdata. When heated to decomposition it emits very toxicfumes of HCl and NOx.

Upstream product

• 100-52-7 benzaldehyde 
• 28867-76-7 benzaldehyde benzylidenehydrazone 
• 561067-10-5 N-benzyl-N'-isopropylidene-hydrazinecarboxylic acid tert-butyl ester 
• 24469-50-9 t-butyl 3-benzylidenecarbazate 
• 100-51-6 benzyl alcohol 
• 287729-00-4 N-benzyl-N-tert-butyloxycarbonylaminophthalimide 
• 185456-43-3 N-benzyl-N’-[(tert-butoxy)carbonyl](tert-butoxy)carbohydrazide 
• 147688-34-4 tert-butyl 1-benzylhydrazine-1-carboxylate 
• 13211-11-5 benzaldehyde benzylhydrazone 
• 53370-84-6 N'-benzylhydrazinecarboxylic acid tert-butyl ester 

Downstream Products

• 93019-54-6 1-Ethansulfonyl-1-benzyl-2-benzyliden-hydrazin 
• 81468-07-7 3-(3-benzyl-thiocarbazoyl-thio)-propionsaeure 
• 219631-08-0 6-benzyl pyrazolo<3,4-d>pyridazin-7(6H)one 
• 32286-78-5 1-benzyl-4,5,6,7-tetrahydro-1H-indazole 
• 654058-90-9 methyl 5-(4-methylthiophenyl)-1-benzylpyrazole-3-carboxylate 
• 957133-21-0 1-benzyl-4-bromo-1,2-dihydropyridazine-3,6-dione 

Relevant articles and documents

N-Amino-1,8-Naphthalimide is a Regenerated Protecting Group for Selective Synthesis of Mono-N-Substituted Hydrazines and Hydrazides

A new route to synthesis of various mono-N-substituted hydrazines and hydrazides by involving in a new C?N bond formation by using N-amino-1,8-naphthalimide as a regenerated precursor was invented. Aniline and phenylhydrazines are reproduced upon reacting these individually with 1,8-naphthalic anhydride followed by hydrazinolysis. The practicality and simplicity of this C?N dihalo alkanes; developed a synthon for bond formation protocol was exemplified to various hydrazines and hydrazides. N-amino-1,8-naphthalimide is suitable synthon for transformation for selective formation of mono-substituted hydrazine and hydrazide derivatives. Those are selective mono-amidation of hydrazine with acid halides; mono-N-substituted hydrazones from aldehydes; synthesis of N-aminoazacycloalkanes from acetohydrazide scaffold and inserted to hydroxy derivatives; distinct synthesis of N,N-dibenzylhydrazines and N-benzylhydrazines from benzyl halides; synthesis of N-amino-amino acids from α-halo esters. Ecofriendly reagent N-amino-1,8-naphthalimide was regenerated with good yields by the hydrazinolysis in all procedures.

Simple preparation of monoalkylhydrazines

Alkylation of t-butyl isopropylidene carbazate with alkyl bromides occurs under phase-transfer conditions. Acid hydrolysis of the product completes a simple two-step synthesis of monoalkylhydrazines.

N-tert-butoxycarbonylaminophthalimide, a versatile reagent for the conversion of alcohols into alkylated tert-butylcarbazates or hydrazines via the Mitsunobu protocol

An efficient two-step method has been developed for the conversion of alcohols to substituted hydrazines. The use of N-tert- butoxycarbonylaminophthalimide as an acid partner in Mitsunobu reactions with a variety of alcohols permits the synthesis of the corresponding monoalkylated tert-butylcarbazates and hydrazines.