- Method for efficiently synthesizing N-3-isooxazole tert-butyl carbamate
-
The invention discloses a method for efficiently synthesizing N-3-isooxazole tert-butyl carbamate. The synthetic route comprises the following steps: brominating a compound A to obtain a compound B, and reacting the compound B and a compound C to obtain a compound D; and reacting the compound D and di-tert-butyl dicarbonate ester, thereby obtaining the compound E. The reaction formula is as shownin the specification. The process method for synthesizing 3-aminoisoxazole is simple in process, cheap and readily available in raw materials, simple and convenient in operation and extremely suitablefor large-scale industrial production, and has very wide industrial application prospects and market value.
- -
-
Paragraph 0030; 0034
(2019/03/08)
-
- SUBSTITUTED ISOXAZOLINES AND THEIR USE AS ANTIBACTERIAL AGENTS
-
Compounds of formula (I), or a pharmaceutically-acceptable salt, or an in-vivo-hydrolysable ester thereof, wherein, for example, X is O, S or NH; HET is an optionally substituted C-linked 5-membered heteroaryl ring containing 2 to 4 heteroatoms independently selected from N, O and S; Q is selected from, for example, Q1 and Q2: R2 and R3 are independently hydrogen or fluoro; T is selected from a range of groups, for example, an N-linked (fully unsaturated) 5-membered heteroaryl ring system or a group of formula (TC5): wherein Rc is, for example, R13CO-, R13SO2- or R13CS-; wherein R13 is, for example, optionally substituted (1-10C)alkyl or R14C(O)O(1-6C)alkyl wherein R14 is optionally substituted (1-10C)alkyl; are useful as antibacterial agents; and processes for their manufacture and pharmaceutical compositions containing them are described
- -
-
-
- SUBSTITUTED ISOXAZOLES AND THE USE THEREOF AS ANTIBIOTICS
-
Compounds of formula (I), wherein X is O, S, NH, OCO, NH-CO, NH-COO, NH-CO-NH, NH-CS or NH-CS-NH; R4 is H, (C1-C3)-alkyl optionally substituted by halogen, or a C-linked heterocyclic radical selected from several possibilities; R1 an
- -
-
-
- HETEROCYCLYLAMINOMETHYLOXAZOLIDINONES AS ANTIBACTERIALS
-
Compounds of formula (I) or a pharmaceutically-acceptable salt, or an in-vivo hydrolysable ester thereof, wherein, for example,HET is an optionally substituted C-linked 5-membered heteroaryl ring containing 2 to 4 heteroatoms independently selected from N
- -
-
Page/Page column 42
(2010/01/31)
-