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CAS

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264622-53-9

MRS 1706 is a selective adenosine A2B receptor inverse agonist, characterized by its high binding affinity to human A2B, A1, A2A, and A3 receptors with Ki values of 1.39, 157, 112, and 230 nM, respectively.

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  • N-(4-Acetylphenyl)-2-(4-(2,6-dioxo-1,3-dipropyl-2,3,6,9-tetrahydro-1H-purin-8-yl)phenoxy)acetamide

    Cas No: 264622-53-9

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  • N-(4-acetylphenyl)-2-[4-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)phenoxy]acetamide

    Cas No: 264622-53-9

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  • 264622-53-9 Structure

  • Basic information

    1. Product Name: MRS 1706
    2. Synonyms: N-(4-ACETYLPHENYL)-2-[4-(2,3,6,7-TETRAHYDRO-2,6-DIOXO-1,3-DIPROPYL-1H-PURIN-8-YL)PHENOXY]ACETAMIDE;MRS 1706;N-(4-acetylphenyl)-2-[4-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)phenoxy]acetamide
    3. CAS NO:264622-53-9
    4. Molecular Formula: C27H29N5O5
    5. Molecular Weight: 503.55
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 264622-53-9.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.293±0.06 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: Store at +4°C
    8. Solubility: N/A
    9. PKA: 8.25±0.70(Predicted)
    10. CAS DataBase Reference: MRS 1706(CAS DataBase Reference)
    11. NIST Chemistry Reference: MRS 1706(264622-53-9)
    12. EPA Substance Registry System: MRS 1706(264622-53-9)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 264622-53-9(Hazardous Substances Data)

264622-53-9 Usage

Uses

Used in Pharmaceutical Industry:
MRS 1706 is used as a selective and potent inverse agonist for the adenosine A2B receptor, which plays a crucial role in various physiological and pathological processes. Its high binding affinity makes it a promising candidate for the development of new therapeutic strategies targeting adenosine receptor-mediated diseases.
Used in Research Applications:
MRS 1706 is used as a research tool to study the role of adenosine A2B receptors in cellular and molecular processes. Its selective binding to the A2B receptor allows researchers to investigate the specific functions and interactions of this receptor in various experimental settings, contributing to a better understanding of adenosine receptor biology and its potential therapeutic applications.
Used in Drug Development:
MRS 1706 is used as a lead compound in the development of new drugs targeting adenosine A2B receptors. Its high selectivity and potency make it an attractive starting point for the design and optimization of novel therapeutic agents with improved pharmacological properties, such as increased selectivity, better bioavailability, and reduced side effects.

Biological Activity

Potent and selective adenosine A 2B receptor inverse agonist (K i values are 1.39, 157, 112 and 230 nM for human A 2B , A 1 , A 2A and A 3 receptors respectively).

Check Digit Verification of cas no

The CAS Registry Mumber 264622-53-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,6,4,6,2 and 2 respectively; the second part has 2 digits, 5 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 264622-53:
(8*2)+(7*6)+(6*4)+(5*6)+(4*2)+(3*2)+(2*5)+(1*3)=139
139 % 10 = 9
So 264622-53-9 is a valid CAS Registry Number.

264622-53-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name N-(4-acetylphenyl)-2-[4-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)phenoxy]acetamide

1.2 Other means of identification

Product number -
Other names MRS 1706

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:264622-53-9 SDS

264622-53-9Downstream Products

264622-53-9Relevant articles and documents

Anilide derivatives of an 8-phenylxanthine carboxylic congener are highly potent and selective antagonists at human A(2B) adenosine receptors

Kim, Yong-Chul,Ji, Xiao-Duo,Melman, Neli,Linden, Joel,Jacobson, Kenneth A.

, p. 1165 - 1172 (2007/10/03)

No highly selective antagonists of the A(2B) adenosine receptor (AR) have been reported; however such antagonists have therapeutic potential as antiasthmatic agents. Here we report the synthesis of potent and selective A(2B) receptor antagonists. The stru

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