Syntheses based on monocarbon molecules: II. Synthesis of ethyl isovalerate by isobutene carbonylation with carbon monoxide and ethanol in the presence of phosphine palladium complexes. Ethyl α-bromoisovalerate
Optimal conditions for the synthesis of ethyl isovalerate by isobutene hydrocarbalkoxylation with carbon monoxide and ethanol in the presence of the catalytic system PdCl2(PPh3)2 + PPh3 + p-TsOH were found. Bromination of ethyl isovalerate under conditions of the Hell-Volgard-Zelinskii reaction gave ethyl α-bromoisovalerate which is the main active component in korvalol medicine.
Suerbaev,Abyzbekova,Shalmagambetov,Zhubanov
p. 516 - 517
(2007/10/03)
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