26464-05-1

Basic information

• Product Name: 2-Bromo-3-methylbutanoyl bromide
• Synonyms: 2-Bromo-3-methyl-1-oxobutyl bromide;2-Bromo-3-methyl-butanoylbromide;alpha-bromoisovaleroylbromide;ALPHA-BROMOISOVALERYL BROMIDE;2-BROMO-3-METHYLBUTYRYL BROMIDE;2-Bro-moisopentanoyl bromide
• CAS NO: 26464-05-1
• Molecular Formula: C₅H₈Br₂O
• Molecular Weight: 243.92
• EINECS: 247-719-8
• Mol File: 26464-05-1.mol

Chemical Properties

• Boiling Point: 190.2 °C at 760 mmHg
• Flash Point: 61.5 °C
• Appearance: Clear colourless to slightly yellow liquid
• Density: 1.802 g/cm³
• Vapor Pressure: 0.548mmHg at 25°C
• Refractive Index: 1.512
• CAS DataBase Reference: 2-Bromo-3-methylbutanoyl bromide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Bromo-3-methylbutanoyl bromide(26464-05-1)
• EPA Substance Registry System: 2-Bromo-3-methylbutanoyl bromide(26464-05-1)

Safety Data

• Hazardous Substances Data: 26464-05-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-Bromo-3-methylbutanoyl bromide is used as a reagent for the synthesis of various pharmaceuticals, contributing to the development of new drugs and medicinal compounds. Its role in this industry is crucial for creating the building blocks of certain medications.
Used in Agrochemical Industry:
In the agrochemical sector, 2-Bromo-3-methylbutanoyl bromide serves as a reagent in the preparation of agrochemicals, playing a part in the creation of substances that protect crops and enhance agricultural productivity.
Used as an Intermediate in Organic Synthesis:
Beyond its direct applications, 2-Bromo-3-methylbutanoyl bromide is also used as an intermediate in the synthesis of a range of other organic compounds, highlighting its versatility in chemical reactions and its importance in the broader field of organic chemistry.
Safety Note:
Given the reactive nature and potential hazards of 2-Bromo-3-methylbutanoyl bromide, it is imperative to follow proper handling procedures and implement safety precautions when working with this chemical compound.

InChI:InChI=1/C5H8Br2O/c1-3(2)4(6)5(7)8/h3-4H,1-2H3

Upstream product

• 503-74-2 3-methylbutyric acid 
• 108-64-5 Ethyl isovalerate 

Downstream Products

• 94107-40-1 N-[N-(α-bromo-isovaleryl)-glycyl]-glycine 
• 847453-58-1 2-bromo-1-(4-bromophenyl)-3-methylbutan-1-one 
• 871886-71-4 2-chloro-1-(2-hydroxy-5-methyl-phenyl)-3-methyl-butan-1-one 
• 101432-51-3 4-(α-bromo-isovaleryl)-1,5-dimethyl-2-phenyl-1,2-dihydro-pyrazol-3-one 
• 609-12-1 ethyl 2-bromoisovalerate 
• 908572-71-4 N-((Ξ)-α-bromo-isovaleryl)-L-tyrosine ethyl ester 
• 94107-41-2 N-(α-bromo-isovaleryl)-phenylalanine 
• 94572-08-4 2-bromo-N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-3-methyl-butyramide 
• 672963-84-7 N-benzoyl-2-bromo-3-methylbutanamide 
• 1016690-07-5 α-bromo-isovaleric acid-(N-ethyl-anilide) 

Relevant articles and documents

Syntheses based on monocarbon molecules: II. Synthesis of ethyl isovalerate by isobutene carbonylation with carbon monoxide and ethanol in the presence of phosphine palladium complexes. Ethyl α-bromoisovalerate

Optimal conditions for the synthesis of ethyl isovalerate by isobutene hydrocarbalkoxylation with carbon monoxide and ethanol in the presence of the catalytic system PdCl2(PPh3)2 + PPh3 + p-TsOH were found. Bromination of ethyl isovalerate under conditions of the Hell-Volgard-Zelinskii reaction gave ethyl α-bromoisovalerate which is the main active component in korvalol medicine.