100202-73-1

Upstream product

• 100202-71-9 6-hydrazinopyridine-4-carbinol 
• 16297-09-9 2,3,5,6-tetrafluoropyridine-4-carboxaldehyde 
• 24191-31-9 2,3,5,6-tetrafluoro-4-(1-hydroxymethyl)pyridine 
• 16297-07-7 2,3,5,6-tetrafluoro-4-pyridinecarbonitrile 
• 7758-99-8 copper(II) sulfate 

Downstream Products

• 266312-20-3 2,3,6-trifluoropyridine-4-carboxyaldehyde 

Relevant academic research and scientific papers

Synthesis of tetrakis(multifluoro-4-pyridyl)porphin derivatives as acetylcholinesterase inhibitors

New tetrakis(multifluoro-4-pyridyl)porphin derivatives (2-4) and water soluble porphyrin (5) were synthesized to investigate their interactions with acetylcholinesterase from electric eel. These compounds have been found to be the potent reversible inhibitors of the enzyme with K(i) values of μM range. In addition, porphyrin (5) showed broad spectrum of anticancer activities. (C) 2000 Elsevier Science Ltd. All rights reserved.

Synthesis of difluorinated pyridinecarboxaldehyde via electrophilic fluorination

An efficient synthesis of novel 3,5-difluoropyridine-4-carboxaldehyde using N-fluoro-benzenesulfonimide (NSFi) is described. Difluorination was achieved through the reaction of 3,5-dihalo-1,3-dioxolane pyridine with n-butyllithium followed by N-fluorobenzenesulfonimide at -120 °C in good to high yields. Maintaining the low temperature during the transmetallation was found to be critical for the selective formation of the difluoro-susbstitution over the monofluoro one.

Fluoropyridinylmethyl cyclopropanecarboxylate insecticides

Insecticidal compounds of the formula STR1 formulations thereof, their use for control of foliar or soil-borne insects, their method of preparation and certain novel intermediates for their preparation are disclosed and exemplified.