266353-32-6Relevant articles and documents
Rearrangement of nitropyridylidenemalonate 1-oxides. A novel method for the synthesis of aminopyridine derivatives
Wnuk, Stanislaw F,Lewandowska, Elzbieta,Valdez, Carlos A,Kinastowski, Stefan
, p. 7667 - 7671 (2007/10/03)
Knoevenagel condensation between 3-nitro-2-pyridinecarbaldehyde and diethyl malonate catalyzed by titanium(IV) chloride gave diethyl 3-nitro-2-pyridylidenemalonate which was oxidized with peracetic acid to give corresponding 1-oxide. Reaction of the latte
4-Aminopyridine derivatives with antiamnesic activity
Andreani, Aldo,Leoni, Alberto,Locatelli, Alessandra,Morigi, Rita,Rambaldi, Mirella,Pietra, Claudio,Villetti, Gino
, p. 77 - 82 (2007/10/03)
Acetylcholine (Ach) enhancement, useful in the treatment of Alzheimer's disease (AD), may be obtained by means of ion channel modulators such as 4- aminopyridine (4-AP). 4-AP is also the central ring of tacrine, the first drug approved for the treatment of AD. The synthesis and pharmacological activity of three 4-AP derivatives, prepared with the aim of improving their antiamnesic activity, is here described. In two of these compounds 4-AP is connected to 4-aminobutyric acid (GABA), whereas in the third it is connected to 2-indolinone, i.e., the skeleton of linopirdine, another Ach enhancing agent. The new compounds showed potent antiamnesic activity in comparison with piracetam. (C) 2000 Edition scientifiques et medicales Elsevier SAS.
