42373-30-8

Usage

Uses

Used in Pharmaceutical Industry:
4-AMINO-3-FORMYLPYRIDINE is used as a reagent for the preparation of 2,3-disubstituted 1,6-naphthyridines. These compounds are considered potential diuretic agents, which can be beneficial in the treatment of various medical conditions related to fluid retention and imbalance of electrolytes in the body.

InChI:InChI=1/C6H6N2O/c7-6-1-2-8-3-5(6)4-9/h1-4H,(H2,7,8)

Upstream product

• 86847-71-4 N-(3-formylpyridin-4-yl)-2,2-dimethylpropanamide 
• 116026-93-8 4--3-pyridinecarboxaldehyde 
• 266353-32-6 4-nitro-3-pyridinecarbaldehyde 1-oxide 
• 123367-22-6 (E)-N,N-dimethyl-2-(4-nitro-1-oxidopyridin-3-yl)ethenamine 
• 504-24-5 4-aminopyridine 
• 138116-34-4 4-amino-3-hydroxymethylpyridine 
• 70298-89-4 4-N-pivaloylaminopyridine 
• 98400-69-2 N-(4-pyridyl) t-butyl carbamate 
• 1074-98-2 3-methyl-4-nitropyridine N-oxide 

Downstream Products

• 197507-55-4 8-bromo-[1,6]-naphthyridine-2-carboxylic acid 
• 197507-09-8 N-(2-methoxybenzyl)-2-(1,6)naphthyridinecarboxamide 
• 197507-11-2 [1,6]naphthyridine-2-carboxylic acid 2-isopropoxy-benzylamide 
• 197507-13-4 8-bromo-[1,6]naphthyridine-2-carboxylic acid (2-isopropoxybenzylamide) 
• 227199-41-9 8-vinyl-[1,6]naphthyridine-2-carboxylic acid 2-isopropoxy-benzylamide 
• 863785-89-1 2-phenyl-[1,6]naphthyridin-3-ol 
• 138116-34-4 4-amino-3-hydroxymethylpyridine 
• 850451-53-5 2-(2,6-dichloro-3-nitro-phenyl)-N-(3-formyl-pyridin-4-yl)-acetamide 

Relevant academic research and scientific papers

Synthesis of 6,6'-diamino-2,2'-biquinoline and 2,2'-bi-1,6- naphthyridine

High-yield synthesis and characterization of the new heterocycles 6,6'- diamino-2,2'-biquinoline (3), 6,6'-bis(N,N-dimethyl-amino)-2,2'-biquinoline (4), and 2,2'-bi-1,6-naphthyridine (5) are described. The preparation of 3 and 4 is based on the coupling of 2-amino-6-chloroquinoline and 2-chloro-6- dimethylaminoquinoline in the presence of NiCl2·6H2O/PPh3/Zn in DMF (NiCRA). Compound 5 was synthesized through a condensation reaction of 4- aminopyridine-3-carbaldehyde and butane-2,3-dione.

Ugi three-component reaction of alcohols, amines and isocyanides: A new approach to the synthesis of cyclic amidines

We have developed a novel, simple, efficient and one pot synthetic protocol for the synthesis of cyclic amidines via Ugi three-component reaction of alcohols, amines, and isocyanides.

SUBSTITUTED HETEROCYCLIC AZA DERIVATIVES

The invention relates to heterocyclic aza derivatives as vanilloid receptor ligands, to pharmaceutical compositions containing these compounds and also to these compounds for use in the treatment and/or prophylaxis of pain and further diseases and/or disorders.

Substituted Heterocyclic Aza Compounds

Heterocyclic aza compounds as vanilloid receptor ligands, pharmaceutical compositions containing these compounds and also methods of using these compounds for the treatment and/or inhibition of pain and further diseases and/or disorders.

Kinase inhibitors

Compounds having the formula are useful for inhibiting protein kinases. Also disclosed are compositions which inhibit protein kinases and methods of inhibiting protein kinases in a patient.

Kinase inhibitors

Compounds having the formula are useful for inhibiting protein kinases. Also disclosed are compositions which inhibit protein kinases and methods of inhibiting protein kinases in a patient.

4-Aminopyridine derivatives with antiamnesic activity

Acetylcholine (Ach) enhancement, useful in the treatment of Alzheimer's disease (AD), may be obtained by means of ion channel modulators such as 4- aminopyridine (4-AP). 4-AP is also the central ring of tacrine, the first drug approved for the treatment of AD. The synthesis and pharmacological activity of three 4-AP derivatives, prepared with the aim of improving their antiamnesic activity, is here described. In two of these compounds 4-AP is connected to 4-aminobutyric acid (GABA), whereas in the third it is connected to 2-indolinone, i.e., the skeleton of linopirdine, another Ach enhancing agent. The new compounds showed potent antiamnesic activity in comparison with piracetam. (C) 2000 Edition scientifiques et medicales Elsevier SAS.

Regiospecific Electrophilic Substitution of Aminopyridines: Ortho Lithiation of 2-, 3-, and 4-(Pivaloylamino)pyridines

2- and 4-(pivaloylamino)pyridines have been shown to undergo metalation exclusively at C-3 and these smoothly react with a variety of electrophiles to produce 2,3- and 3,4-disubstituted pyridines, respectively.Removal of the pivaloyl protecting group results in overall electrophilic substitution of an aminopyridine.Utilization of this method is exemplified by efficient syntheses of 2- and 4-aminonicotinaldehydes.Minor modifications of the reaction conditions permitted exclusive ortho metalation of 2-(pivaloylamino)pyridines additionally functionalized by chloro, fluoro, or methyl groups.Although the major product from reaction of 3-(pivaloylamino)pyridine by this method was metalation at C-4, the reaction was complicated by substantial quantities of product derived from nucleophilic attack by n-butyllithium on the pyridine nucleus.