42373-30-8

Basic information

• Product Name: 4-AMINO-3-FORMYLPYRIDINE
• Synonyms: 4-AMINO-3-FORMYLPYRIDINE;4-AMINO-3-PYRIDINECARBOXALDEHYDE;4-AMINONICOTINALDEHYDE;4-AMINO-PYRIDINE-3-CARBALDEHYDE;4-AMINOPYRIDINE-3-CARBOXALDEHYDE;4-Aminopyridine-3-carboxaldehyde,4-Aminonicotinaldehyde;4-Aminopyridine-3-carboxaldehyde, tech. 85%;Zinc01495001
• CAS NO: 42373-30-8
• Molecular Formula: C₆H₆N₂O
• Molecular Weight: 122.12
• Product Categories: Pyridine series;Aldehydes;Pyridines;Pyridine
• Mol File: 42373-30-8.mol
• Article Data: 10

Chemical Properties

• Melting Point: 97-98
• Boiling Point: 342.2 °C at 760 mmHg
• Flash Point: 160.7 °C
• Appearance: White to light yellow to cream/Powder
• Density: 1.264 g/cm³
• Vapor Pressure: 7.66E-05mmHg at 25°C
• Refractive Index: 1.652
• Storage Temp.: Refrigerated.
• Solubility: Chloroform (Sparingly, Heated, Sonicated), DMSO (Slightly), Methanol (Slightly)
• PKA: 6.96±0.12(Predicted)
• Sensitive: Air Sensitive
• CAS DataBase Reference: 4-AMINO-3-FORMYLPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-AMINO-3-FORMYLPYRIDINE(42373-30-8)
• EPA Substance Registry System: 4-AMINO-3-FORMYLPYRIDINE(42373-30-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38-43-22
• Safety Statements: 26-36/37/39-36/37
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 42373-30-8(Hazardous Substances Data)

Usage

Uses

4-Aminonicotinaldehyde acts as a reagent used in the preparation of 2,3-disubstituted 1,6-naphthyridines as a potential diurectic agents.

InChI:InChI=1/C6H6N2O/c7-6-1-2-8-3-5(6)4-9/h1-4H,(H2,7,8)

Upstream product

• 123367-22-6 (E)-N,N-dimethyl-2-(4-nitro-1-oxidopyridin-3-yl)ethenamine 
• 98400-69-2 N-(4-pyridyl) t-butyl carbamate 
• 70298-89-4 4-N-pivaloylaminopyridine 
• 138116-34-4 4-amino-3-hydroxymethylpyridine 
• 504-24-5 4-aminopyridine 
• 1074-98-2 3-methyl-4-nitropyridine N-oxide 
• 266353-32-6 4-nitro-3-pyridinecarbaldehyde 1-oxide 
• 116026-93-8 4--3-pyridinecarboxaldehyde 
• 86847-71-4 N-(3-formylpyridin-4-yl)-2,2-dimethylpropanamide 

Downstream Products

• 1219594-37-2 2-[(2-diphenylphosphoryl)hept-1-yl]-1,6-naphthyridine 
• 1219594-33-8 2-[1-(diphenylphosphoryl)ethyl]-1,6-naphthyridine 
• 1219594-36-1 2-[2-(diphenylphosphoryl-2-methyl)propyl]-1,6-naphthyridine 
• 1219594-34-9 2-[1-(diphenylphosphoryl-1-methyl)ethyl]-1,6-naphthyridine 
• 1219594-39-4 3-[(diphenylphosphoryl)methyl]-2-methyl-1,6-naphthyridine 
• 1219594-38-3 2-[(2-diphenylphosphoryl)ethyl]-1,6-naphthyridine 
• 850450-10-1 N-[2,4-dichloro-3-(1-methyl-2-oxo-1,2-dihydro-[1,6]naphthyridin-3-yl)-phenyl]-4-(4-methyl-piperazin-1-ylmethyl)-benzamide 
• 850450-11-2 N-[2,4-dichloro-3-(1-methyl-2-oxo-1,2-dihydro-[1,6]naphthyridin-3-yl)-phenyl]-3-trifluoromethyl-benzenesulfonamide 
• 850450-13-4 N-[3,5-dichloro-4-(1-methyl-2-oxo-1,2-dihydro-[1,6]naphthyridin-3-yl)-phenyl]-3-trifluoromethyl-benzamide 
• 850450-47-4 N-[4-chloro-3-(2-oxo-1,2-dihydro-[1,6]naphthyridin-3-yl)-phenyl]-3-trifluoromethyl-benzamide 
• 850451-56-8 4-chloromethyl-N-[2,4-dichloro-3-(1-methyl-2-oxo-1,2-dihydro-[1,6]naphthyridin-3-yl)-phenyl]-benzamide 
• 850451-52-4 3-(2,6-dichloro-3-nitro-phenyl)-1H-[1,6]naphthyridin-2-one 
• 850451-63-7 C₁₅H₉Cl₂N₃O₃ 
• 850451-54-6 3-(2,6-dichloro-3-nitro-phenyl)-1-methyl-1H-[1,6]naphthyridin-2-one 

Relevant articles and documents

Synthesis of 6,6'-diamino-2,2'-biquinoline and 2,2'-bi-1,6- naphthyridine

High-yield synthesis and characterization of the new heterocycles 6,6'- diamino-2,2'-biquinoline (3), 6,6'-bis(N,N-dimethyl-amino)-2,2'-biquinoline (4), and 2,2'-bi-1,6-naphthyridine (5) are described. The preparation of 3 and 4 is based on the coupling of 2-amino-6-chloroquinoline and 2-chloro-6- dimethylaminoquinoline in the presence of NiCl2·6H2O/PPh3/Zn in DMF (NiCRA). Compound 5 was synthesized through a condensation reaction of 4- aminopyridine-3-carbaldehyde and butane-2,3-dione.

SUBSTITUTED HETEROCYCLIC AZA DERIVATIVES

The invention relates to heterocyclic aza derivatives as vanilloid receptor ligands, to pharmaceutical compositions containing these compounds and also to these compounds for use in the treatment and/or prophylaxis of pain and further diseases and/or disorders.

Kinase inhibitors

Compounds having the formula are useful for inhibiting protein kinases. Also disclosed are compositions which inhibit protein kinases and methods of inhibiting protein kinases in a patient.