cas 26660-48-0, 6-METHOXYQUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER

Articles about 26660-48-0Total 5 be found

Initial Route Scouting and Final Process Development for the Multi-Kg Production of 3-Fluoro-6-methoxyquinoline from p-Anisidine and 2-Fluoromalonic Acid
A scalable route to 3-fluoro-6-methoxyquinoline needed to be developed as multi-kg amounts of this heterocycle were required. Initial route development focused on the formation of the key C-F bond via a Balz-Schiemann reaction or electrophilic fluorinatio
Sch?fer, Gabriel,Fleischer, Tony,Blumer, Nicole,Udry, Megan,Reber, Stefan,Stansfield, Ian,Liu, Yuanhua,Li, Yan,Li, Pixu
p. 347 - 357
(2022/02/01)

Copper-catalyzed domino SN2′/coupling reaction: A versatile and facile synthesis of cyclic compounds from baylis-hillman acetates
A variety of substituted quinoline/pyridine, thiochromene and naphthalene derivatives, which might be of biological and medicinal value, were synthesized by copper-catalyzed domino SN2′/coupling, SN2′ /deacylation/coupling and SN2′/coupling/elimination reactions. The method provides a general and convenient approach to the synthesis of various substituted cyclic compounds from the corresponding Baylis-Hillman (B-H) acetates and N-/S-/C-nucleophiles. Copyright
Niu, Qingsheng,Mao, Hui,Yuan, Guodong,Gao, Jilong,Liu, Haiquan,Tu, Yawei,Wang, Xiaoxia,Lv, Xin
supporting information
p. 1185 - 1192
(2013/05/22)

Synthesis of 2,4-unsubstituted quinoline-3-carboxylic acid ethyl esters from arylmethyl azides via a domino process
A convenient synthesis of 2,4-unsubstituted quinoline-3-carboxylic acid ethyl esters via a domino process is described. The synthesis employs arylmethyl azides as the precursor which undergoes an acid-promoted rearrangement to give an N-aryl iminium ion. Following the addition with ethyl 3-ethoxyacrylate, intramolecular electrophilic aromatic substitution, elimination and subsequent oxidation, the quinoline products were obtained in moderate to excellent yields.
Tummatorn, Jumreang,Thongsornkleeb, Charnsak,Ruchirawat, Somsak,Gettongsong, Tanita
supporting information
p. 1463 - 1467
(2013/05/08)

Synthesis of quinoline derivatives as 5-HT4 receptor ligands
A general and convenient synthesis of 6-methoxyquinoline-3-carboxamides commencing with a cyclization step that involves -anisidine and diethyl (ethoxymethylene)malonate is described. An additional tetrahydroquinoline scaffold 19 is prepared from 6-methox
Hanna-Elias, Amir,Manallack, David T.,Berque-Bestel, Isabelle,Irving, Helen R.,Coupar, Ian M.,Iskander, Magdy N.
experimental part
p. 150 - 156
(2009/09/08)

Amino acids containing dihydropyridine ring systems for site-specific delivery of peptides to the brain
The invention provides novel amino acids and peptides containing them which comprise a dihydropyridine pyridinium salt-type redox system and which provide site-specific and sustained delivery of pharmacologically active peptides to the brain. These new amino acids contain a redox system appended directly or via an alkylene bridge to the carbon atom adjacent to the carboxyl carbon and may be incorporated into a peptide chain at a variety of positions, including non-terminal positions.
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(2008/06/13)