26660-48-0

Basic information

• Product Name: 6-METHOXYQUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER
• Synonyms: 6-METHOXYQUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER;ethyl 6-methoxyquinoline-3-carboxylate
• CAS NO: 26660-48-0
• Molecular Formula: C13H13NO3
• Molecular Weight: 231.25
• Mol File: 26660-48-0.mol
• Article Data: 5

Chemical Properties

• Melting Point: 203-205 °C
• Boiling Point: 349°Cat760mmHg
• Flash Point: 164.9°C
• Appearance: /
• Density: 1.184g/cm³
• Vapor Pressure: 4.85E-05mmHg at 25°C
• Refractive Index: 1.583
• Storage Temp.: 2-8°C
• PKA: 3.25±0.14(Predicted)
• CAS DataBase Reference: 6-METHOXYQUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 6-METHOXYQUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER(26660-48-0)
• EPA Substance Registry System: 6-METHOXYQUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER(26660-48-0)

Safety Data

• Hazardous Substances Data: 26660-48-0(Hazardous Substances Data)

Usage

General Description

6-METHOXYQUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER is a chemical compound with the molecular formula C13H11NO4. It is a derivative of quinoline, a heterocyclic aromatic organic compound, and is commonly used in pharmaceutical research and development. 6-METHOXYQUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER is known for its antibacterial and antimicrobial properties and has potential applications in the treatment of bacterial infections. It is typically used as a building block in the synthesis of various pharmaceutical compounds and in the study of chemical reactions and mechanisms. Additionally, it may have potential applications in the field of organic synthesis and medicinal chemistry due to its unique structure and properties.

InChI:InChI=1/C13H13NO3/c1-3-17-13(15)10-6-9-7-11(16-2)4-5-12(9)14-8-10/h4-8H,3H2,1-2H3

Upstream product

• 77156-78-6 ethyl 4-hydroxy-6-methoxyquinoline-3-carboxylate 
• 6325-93-5 p-nitrobenzenesulfonamide 
• 2746-25-0 p-Methoxybenzyl bromide 
• 70978-37-9 1-(azidomethyl)-4-methoxybenzene 
• 105-13-5 4-Methoxybenzyl alcohol 
• 22931-71-1 ethyl 4-chloro-6-methoxyquinolin-3-carboxylate 

Downstream Products

• 71083-30-2 6-methoxyquinoline-3-carboxamide 
• 426842-85-5 4-chloro-3-fluoro-6-methoxyquinoline 
• 29507-86-6 3-amino-6-methoxyquinoline 
• 71082-47-8 6-methoxyquinoline-3-carboxylic acid 

Relevant articles and documents

Initial Route Scouting and Final Process Development for the Multi-Kg Production of 3-Fluoro-6-methoxyquinoline from p-Anisidine and 2-Fluoromalonic Acid

A scalable route to 3-fluoro-6-methoxyquinoline needed to be developed as multi-kg amounts of this heterocycle were required. Initial route development focused on the formation of the key C-F bond via a Balz-Schiemann reaction or electrophilic fluorinatio

Synthesis of 2,4-unsubstituted quinoline-3-carboxylic acid ethyl esters from arylmethyl azides via a domino process

A convenient synthesis of 2,4-unsubstituted quinoline-3-carboxylic acid ethyl esters via a domino process is described. The synthesis employs arylmethyl azides as the precursor which undergoes an acid-promoted rearrangement to give an N-aryl iminium ion. Following the addition with ethyl 3-ethoxyacrylate, intramolecular electrophilic aromatic substitution, elimination and subsequent oxidation, the quinoline products were obtained in moderate to excellent yields.

Amino acids containing dihydropyridine ring systems for site-specific delivery of peptides to the brain

The invention provides novel amino acids and peptides containing them which comprise a dihydropyridine pyridinium salt-type redox system and which provide site-specific and sustained delivery of pharmacologically active peptides to the brain. These new amino acids contain a redox system appended directly or via an alkylene bridge to the carbon atom adjacent to the carboxyl carbon and may be incorporated into a peptide chain at a variety of positions, including non-terminal positions.