26660-48-0

Usage

Uses

Used in Pharmaceutical Research and Development:
6-METHOXYQUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER is used as a key building block for the synthesis of various pharmaceutical compounds, contributing to the development of new drugs with potential therapeutic applications.
Used in Antibacterial and Antimicrobial Applications:
Due to its inherent antibacterial and antimicrobial properties, 6-METHOXYQUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER is used in the treatment of bacterial infections, offering a potential solution to combat resistant strains of bacteria.
Used in Organic Synthesis:
6-METHOXYQUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER is utilized in the field of organic synthesis, where its unique structure and properties are leveraged to create novel organic compounds with specific functionalities.
Used in Medicinal Chemistry:
In medicinal chemistry, 6-METHOXYQUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER is employed for the study of chemical reactions and mechanisms, aiding in the understanding of drug action and the design of more effective pharmaceutical agents.
Used in Chemical Reactions and Mechanisms Study:
6-METHOXYQUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER is used as a model compound in the study of chemical reactions and mechanisms, providing insights into the behavior of similar compounds and their potential applications in various chemical processes.

InChI:InChI=1/C13H13NO3/c1-3-17-13(15)10-6-9-7-11(16-2)4-5-12(9)14-8-10/h4-8H,3H2,1-2H3

Upstream product

• 77156-78-6 ethyl 4-hydroxy-6-methoxyquinoline-3-carboxylate 
• 6325-93-5 p-nitrobenzenesulfonamide 
• 2746-25-0 p-Methoxybenzyl bromide 
• 70978-37-9 1-(azidomethyl)-4-methoxybenzene 
• 105-13-5 4-Methoxybenzyl alcohol 
• 22931-71-1 ethyl 4-chloro-6-methoxyquinolin-3-carboxylate 

Downstream Products

• 71083-30-2 6-methoxyquinoline-3-carboxamide 
• 426842-85-5 4-chloro-3-fluoro-6-methoxyquinoline 
• 29507-86-6 3-amino-6-methoxyquinoline 
• 71082-47-8 6-methoxyquinoline-3-carboxylic acid 

Relevant academic research and scientific papers

Initial Route Scouting and Final Process Development for the Multi-Kg Production of 3-Fluoro-6-methoxyquinoline from p-Anisidine and 2-Fluoromalonic Acid

A scalable route to 3-fluoro-6-methoxyquinoline needed to be developed as multi-kg amounts of this heterocycle were required. Initial route development focused on the formation of the key C-F bond via a Balz-Schiemann reaction or electrophilic fluorinatio

Copper-catalyzed domino SN2′/coupling reaction: A versatile and facile synthesis of cyclic compounds from baylis-hillman acetates

A variety of substituted quinoline/pyridine, thiochromene and naphthalene derivatives, which might be of biological and medicinal value, were synthesized by copper-catalyzed domino SN2′/coupling, SN2′ /deacylation/coupling and SN2′/coupling/elimination reactions. The method provides a general and convenient approach to the synthesis of various substituted cyclic compounds from the corresponding Baylis-Hillman (B-H) acetates and N-/S-/C-nucleophiles. Copyright

Synthesis of 2,4-unsubstituted quinoline-3-carboxylic acid ethyl esters from arylmethyl azides via a domino process

A convenient synthesis of 2,4-unsubstituted quinoline-3-carboxylic acid ethyl esters via a domino process is described. The synthesis employs arylmethyl azides as the precursor which undergoes an acid-promoted rearrangement to give an N-aryl iminium ion. Following the addition with ethyl 3-ethoxyacrylate, intramolecular electrophilic aromatic substitution, elimination and subsequent oxidation, the quinoline products were obtained in moderate to excellent yields.

Synthesis of quinoline derivatives as 5-HT4 receptor ligands

A general and convenient synthesis of 6-methoxyquinoline-3-carboxamides commencing with a cyclization step that involves -anisidine and diethyl (ethoxymethylene)malonate is described. An additional tetrahydroquinoline scaffold 19 is prepared from 6-methox

Amino acids containing dihydropyridine ring systems for site-specific delivery of peptides to the brain

The invention provides novel amino acids and peptides containing them which comprise a dihydropyridine pyridinium salt-type redox system and which provide site-specific and sustained delivery of pharmacologically active peptides to the brain. These new amino acids contain a redox system appended directly or via an alkylene bridge to the carbon atom adjacent to the carboxyl carbon and may be incorporated into a peptide chain at a variety of positions, including non-terminal positions.