267644-49-5

Basic information

• Product Name: 2-Aminocarbonyl-5-nitrobenzofuran
• Synonyms: 2-Aminocarbonyl-5-nitrobenzofuran;2-BenzofurancarboxaMide, 5-nitro-;5-nitro-1-benzofuran-2-carboxamide
• CAS NO: 267644-49-5
• Molecular Formula: C9H6N2O4
• Molecular Weight: 206.15
• Product Categories: API intermediates
• Mol File: 267644-49-5.mol

Chemical Properties

• Boiling Point: 461.7±25.0 °C(Predicted)
• Appearance: /
• Density: 1.505±0.06 g/cm3(Predicted)
• PKA: 15.18±0.30(Predicted)
• CAS DataBase Reference: 2-Aminocarbonyl-5-nitrobenzofuran(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Aminocarbonyl-5-nitrobenzofuran(267644-49-5)
• EPA Substance Registry System: 2-Aminocarbonyl-5-nitrobenzofuran(267644-49-5)

Safety Data

• Hazardous Substances Data: 267644-49-5(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-Aminocarbonyl-5-nitrobenzofuran is used as a key intermediate in the synthesis of pharmaceutical compounds for its versatile reactivity and potential for functionalization, contributing to the development of new drugs with improved therapeutic properties.
Used in Materials Science:
In the field of materials science, 2-Aminocarbonyl-5-nitrobenzofuran is utilized as a component in the creation of novel materials that leverage its unique electronic and photophysical properties, enhancing the performance of materials in various applications such as optoelectronics and photonics.
Used in Chemical Research:
2-Aminocarbonyl-5-nitrobenzofuran is employed as a research tool in chemical studies, where its interesting properties are explored for understanding fundamental chemical reactions and mechanisms, potentially leading to the discovery of new chemical processes and compounds.

Upstream product

• 69604-00-8 ethyl 5-nitrobenzo[d]furan-2-carboxylate 
• 97-51-8 5-Nitrosalicylaldehyde 
• 90036-16-1 5-nitrobenzofuran-2-carbonyl chloride 
• 125418-93-1 2-(2-formyl-4-nitrophenoxy)acetonitrile 
• 10242-12-3 5-nitrobenzofuran-2-carboxylic acid 
• 6965-69-1 2-(2-formyl-4-nitrophenoxy)acetic acid 
• 90-02-8 salicylaldehyde 
• 6280-80-4 2-Formylphenoxyacetic acid 

Downstream Products

• 183288-46-2 5-(1-piperazinyl)benzofuran-2-carboxamide 
• 163521-12-8 vilazodone 
• 53020-42-1 5-hydroxybenzofuran-2-carbonitrile 
• 916737-84-3 5-aminobenzofuran-2-carbonitrile 

Relevant articles and documents

Probes for imidazoline binding sites: Synthesis and evaluation of a selective, irreversible I2 ligand

An irreversible ligand (7) has been prepared based on the selective I2 ligand 2-BFI. Compound 7 displayed high affinity and selectivity for I2-sites and has been shown to irreversibly bind to these sites in rat brain. Compound 7 should, therefore, prove an invaluable tool for the further elucidation of I2-site function. (C) 2000 Elsevier Science Ltd. All rights reserved.

Method for preparing benzofuran-2-carboxamide compound

The invention discloses a method for preparing a benzofuran-2-carboxamide compound. The method comprises the following steps: sequentially adding an alkali and a 2-formylaryloxy acetonitrile derivative into a solvent, and carrying out a reaction at a certain temperature to obtain a reaction solution after complete reaction; and sequentially subjecting the reaction solution to extraction, drying, concentration and column chromatographic separation to obtain a target product, i.e., the benzofuran-2-carboxamide compound. According to the invention, common cheap easily-available inorganic base ororganic base is used as a catalyst of the reaction, no metal or organic catalyst is used, and no additive is needed; reaction conditions are mild; product yield is high; operation is simple; and the method is environment-friendly. Reagents and the catalyst used in the method are rich in industrial sources and easy to obtain, so production cost is low; product purity is high; and the method has good industrial application prospects.

Pyrimidine heterocyclic compounds, pyrimidine heterocyclic compound salts, and preparation method and application thereof

The invention provides pyrimidine heterocyclic compounds, pyrimidine heterocyclic compound salts, and a preparation method and application thereof. According to the pyrimidine heterocyclic compounds provided by the invention, specific Rq is selected, so that the obtained compounds have favorable drug resistance and long half life when being used as the medicine for treating or preventing HIV. The compounds have the advantages of high activity, low toxicity and high stability.

POLYMORPHIC FORM OF 5-(4-[4-(5-CYANO-1H-INDOL-3-YL) BUTYL] PIPERAZIN-1-YL) BENZOFURAN-2-CARBOXAMIDE AND PROCESS FOR PREPARING THEREOF

The present invention provides a solid state Form-Z of 5-(4-[4-(5-cyano-1H-indol-3-yl)butyl]piperazin-1-yl)benzofuran-2-carboxamide. The present invention also provides a process for preparing Form-Z of 5-(4-[4-(5-cyano-1H-indol-3-yl)butyl]piperazin-1-yl)benzofuran-2-carboxamide comprising the steps of i) reacting solid state form of 5-(1-piperazinyl)benzofuran-2-carboxamide or its salts with 3-(4-chlorobutyl)-1H-indole-5-carbonitrile an organic solvent in presence of a base to obtain crude vilazodone free base; ii) purifying the crude vilazodone free base of step (i) in an organic solvent; iii) treating the purified vilazodone free base of step (ii) with an organic solvent to obtain solid state form-Z of vilazodone. The present invention further provides a pharmaceutical composition comprising a therapeutically effective amount of an amorphous form of vilazodone hydrochloride and use of solid state Form-Z of vilazodone for the treatment of major depressive disorders.

PROCESS FOR THE PREPARATION OF VILAZODONE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF

The present invention provides a novel intermediate of vilazodone and its process of preparation. The present invention further provides a process for preparing vilazodone or a pharmaceutically acceptable salt thereof using said novel intermediate.

POLYMORPHIC FORM OF 5-(4-[4-(5-CYANO-1H-INDOL-3- YL)BUTYL]PIPERAZIN-1-YL) BENZOFURAN-2-CARBOXAMIDE

The present invention relates to a process for the preparation of 5-(4-[4-(5- cyano- 1 H-indol-3 -yl)butyl] piperazin- 1 -yl)benzofuran-2-carboxamide of Formula (1) or its pharmaceutically acceptable salt, solvates or hydrates thereof. In particular, the present invention provides a novel intermediate compound, 5-(4-substitutedpiperazin- 1-yl)benzofuran-2-carboxamide of Formula (X). The present invention further provides solid state form of 5-(4-[4-(5-cyano-1H-indol-3- yl) butyl]piperazin-1-yl)benzofuran-2-carboxamide of Formula (1) and process for its preparation.