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5-Nitrobenzofuran-2-carboxylic acid
Cas No: 10242-12-3
No Data 10 Milligram Amadis Chemical Co., Ltd. Contact Supplier
5-nitrobenzofuran-2-carboxylic acid
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USD $ 3.0-3.0 / Kilogram 1 Kilogram 1-100 Metric Ton/Month Dayang Chem (Hangzhou) Co.,Ltd. Contact Supplier
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5-Nitrobenzofuran-2-carboxylic acid 10242-12-3
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High Purity 5-nitrobenzofuran-2-carboxylic acid Cas No: 10242-12-3
Cas No: 10242-12-3
USD $ 1.0-3.0 / Gram 10 Gram 1000 Kilogram/Month Wuhan Monad Medicine Tech Co.,LTD Contact Supplier
Manufacturer Supply Top quality 5-Nitro-1-benzofuran-2-carboxylic acid
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5-Nitrobenzofuran-2-carboxylic acid
Cas No: 10242-12-3
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5-Nitrobenzofuran-2-carboxylic acid
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5-Nitro-1-benzofuran-2-carboxylic acid
Cas No: 10242-12-3
USD $ 100.0-100.0 / Kilogram 1 Kilogram 10000 Kilogram/Day Metric Ton/Day Zibo Hangyu Import&Export Co., Ltd Contact Supplier
5-Nitrobenzofuran-2-carboxylic acid
Cas No: 10242-12-3
USD $ 10.0-10.0 / Gram 1 Gram 10000 Kilogram/Day Zhejiang J&C Biological Technology Co.,Limited Contact Supplier

10242-12-3 Usage

Uses

Reactant for:• ;Preparation of arylarylamidobenzofurans via Curtius rearrangement followed by bromination and Suzuki reaction1• ;Synthesis and antibacterial evaluation of nitazoxanide-based analogs2• ;Preparation of Melanin-Concentrating Hormone Receptor 1 antagonist3• ;Synthesis of benzoyl and cinnamoyl nitrogen mustard derivatives of benzoheterocyclic analogs of tallimustine as antitumor agents4

Chemical Properties

Light yellow powder
InChI:InChI=1/C9H5NO5/c11-9(12)8-4-5-3-6(10(13)14)1-2-7(5)15-8/h1-4H,(H,11,12)/p-1

10242-12-3 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
Aldrich (716383)  5-Nitrobenzofuran-2-carboxylicacid  97% 10242-12-3 716383-1G 512.46CNY Detail

10242-12-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name 5-Nitrobenzofuran-2-carboxylic acid

1.2 Other means of identification

Product number -
Other names 5-nitro-1-benzofuran-2-carboxylic acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:10242-12-3 SDS

10242-12-3Synthetic route

ethyl 5-nitrobenzo[d]furan-2-carboxylate
69604-00-8

ethyl 5-nitrobenzo[d]furan-2-carboxylate

5-nitrobenzofuran-2-carboxylic acid
10242-12-3

5-nitrobenzofuran-2-carboxylic acid

Conditions
ConditionsYield
With water; sodium hydroxide In tetrahydrofuran; methanol at 25℃; for 3h;100%
With water; sodium hydroxide In methanol for 0.5h; Heating;95%
With methanol; sodium hydroxide for 0.5h;82%
With potassium hydroxide; phosphoric acid In ethanol; water
With water; sodium hydroxide In tetrahydrofuran; methanol at 70℃; for 1h;
3-(2-hydroxy-5-nitrophenyl)acrylic acid
50396-49-1

3-(2-hydroxy-5-nitrophenyl)acrylic acid

5-nitrobenzofuran-2-carboxylic acid
10242-12-3

5-nitrobenzofuran-2-carboxylic acid

Conditions
ConditionsYield
With caesium carbonate; copper dichloride In N,N-dimethyl-formamide at 100℃; for 5h; Solvent; Reagent/catalyst;85%
2-(2-formyl-4-nitrophenoxy)acetic acid
6965-69-1

2-(2-formyl-4-nitrophenoxy)acetic acid

A

5-nitrobenzofuran-2-carboxylic acid
10242-12-3

5-nitrobenzofuran-2-carboxylic acid

B

5-nitrobenzofuran
18761-31-4

5-nitrobenzofuran

Conditions
ConditionsYield
With sodium acetate; acetic anhydride at 110℃; for 3h;A 73.9%
B 25.3%
Benzofuran-2-carboxylic acid
496-41-3

Benzofuran-2-carboxylic acid

A

2,6-dinitro-benzofuran
69227-70-9

2,6-dinitro-benzofuran

B

2,5-dinitrobenzofuran
69227-69-6

2,5-dinitrobenzofuran

C

5-nitrobenzofuran-2-carboxylic acid
10242-12-3

5-nitrobenzofuran-2-carboxylic acid

Conditions
ConditionsYield
With nitric acid; tin(IV) chloride In dichloromethane at 0℃; for 2h;A 16%
B 16%
C 39%
Benzofuran-2-carboxylic acid
496-41-3

Benzofuran-2-carboxylic acid

A

2-nitro-benzofuran
33094-66-5

2-nitro-benzofuran

B

6-nitro-1-benzofuran-2-carboxylic acid
64209-68-3

6-nitro-1-benzofuran-2-carboxylic acid

C

5-nitrobenzofuran-2-carboxylic acid
10242-12-3

5-nitrobenzofuran-2-carboxylic acid

Conditions
ConditionsYield
With nitric acid; tin(IV) chloride In dichloromethane at 0℃; for 2h;A 5%
B 33%
C 33%
2-formyl-4-nitrophenoxyacetic acid ethyl ester
51336-43-7

2-formyl-4-nitrophenoxyacetic acid ethyl ester

A

5-nitrobenzofuran-2-carboxylic acid
10242-12-3

5-nitrobenzofuran-2-carboxylic acid

B

ethyl 5-nitrobenzo[d]furan-2-carboxylate
69604-00-8

ethyl 5-nitrobenzo[d]furan-2-carboxylate

(2R,3S)-3-Hydroxy-5-nitro-2,3-dihydro-benzofuran-2-carboxylic acid ethyl ester
104862-16-0, 104862-20-6

(2R,3S)-3-Hydroxy-5-nitro-2,3-dihydro-benzofuran-2-carboxylic acid ethyl ester

(2S,3S)-3-Hydroxy-5-nitro-2,3-dihydro-benzofuran-2-carboxylic acid ethyl ester
104862-16-0, 104862-20-6

(2S,3S)-3-Hydroxy-5-nitro-2,3-dihydro-benzofuran-2-carboxylic acid ethyl ester

Conditions
ConditionsYield
With potassium hydroxide In 1,4-dioxane for 1h; Heating;A 0.5%
B 1%
C n/a
D n/a
With potassium hydroxide In 1,4-dioxane for 1h; Heating; Yields of byproduct given;A 0.5%
B 1%
C n/a
D n/a
With potassium hydroxide In 1,4-dioxane for 1h; Heating; Yield given. Yields of byproduct given;A 0.5%
B 1%
C n/a
D n/a
3-bromo-6-nitro-2H-chromen-2-one
5415-73-6

3-bromo-6-nitro-2H-chromen-2-one

5-nitrobenzofuran-2-carboxylic acid
10242-12-3

5-nitrobenzofuran-2-carboxylic acid

Conditions
ConditionsYield
With potassium hydroxide; ethanol
ethyl 5-nitrobenzo[d]furan-2-carboxylate
69604-00-8

ethyl 5-nitrobenzo[d]furan-2-carboxylate

A

5-nitrobenzofuran-2-carboxylic acid
10242-12-3

5-nitrobenzofuran-2-carboxylic acid

B

5-nitrobenzofuran
18761-31-4

5-nitrobenzofuran

Conditions
ConditionsYield
With potassium hydroxide
Diethyl 2-bromomalonate
685-87-0

Diethyl 2-bromomalonate

5-Nitrosalicylaldehyde
97-51-8

5-Nitrosalicylaldehyde

A

5-nitrobenzofuran-2-carboxylic acid
10242-12-3

5-nitrobenzofuran-2-carboxylic acid

B

ethyl 5-nitrobenzo[d]furan-2-carboxylate
69604-00-8

ethyl 5-nitrobenzo[d]furan-2-carboxylate

Conditions
ConditionsYield
With potassium carbonate; butanone
2-formyl-<4-nitro-phenoxy>-acetic acid

2-formyl-<4-nitro-phenoxy>-acetic acid

5-nitrobenzofuran-2-carboxylic acid
10242-12-3

5-nitrobenzofuran-2-carboxylic acid

Conditions
ConditionsYield
With sodium acetate; acetic anhydride at 160℃;
3-bromo-2H-chromen-2-one
939-18-4

3-bromo-2H-chromen-2-one

5-nitrobenzofuran-2-carboxylic acid
10242-12-3

5-nitrobenzofuran-2-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: glacial acetic acid; HNO3+H2SO4
2: alcohol; KOH-solution
View Scheme
ethyl coumarilate
3199-61-9

ethyl coumarilate

5-nitrobenzofuran-2-carboxylic acid
10242-12-3

5-nitrobenzofuran-2-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: acetic acid anhydride; sulfuric acid; nitric acid
2: ethanolic KOH-solution
View Scheme
5-Nitrosalicylaldehyde
97-51-8

5-Nitrosalicylaldehyde

5-nitrobenzofuran-2-carboxylic acid
10242-12-3

5-nitrobenzofuran-2-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: potassium carbonate; butanone
2: ethanolic KOH-solution
View Scheme
Multi-step reaction with 2 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 20 °C
1.2: 85 °C
2.1: sodium hydroxide; methanol / 0.5 h
View Scheme
2-Formylphenoxyacetic acid
6280-80-4

2-Formylphenoxyacetic acid

5-nitrobenzofuran-2-carboxylic acid
10242-12-3

5-nitrobenzofuran-2-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: sulfuric acid; nitric acid / 5 - 35 °C
2.1: acetic anhydride / 0.25 h / 35 °C
2.2: 8 h / 125 °C
View Scheme
salicylaldehyde
90-02-8

salicylaldehyde

5-nitrobenzofuran-2-carboxylic acid
10242-12-3

5-nitrobenzofuran-2-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: sodium hydroxide / water / 3 h / 30 - 100 °C
2.1: sulfuric acid; nitric acid / 5 - 35 °C
3.1: acetic anhydride / 0.25 h / 35 °C
3.2: 8 h / 125 °C
View Scheme
Multi-step reaction with 3 steps
1.1: sodium hydroxide / water / 3 h / 30 - 100 °C
2.1: sulfuric acid / water / 0.25 h / 5 - 35 °C
2.2: 2.25 h / 5 - 35 °C
3.1: acetic anhydride / 0.25 h / 35 °C
3.2: 8 h / 125 °C
View Scheme
2-(2-formyl-4-nitrophenoxy)acetic acid
6965-69-1

2-(2-formyl-4-nitrophenoxy)acetic acid

5-nitrobenzofuran-2-carboxylic acid
10242-12-3

5-nitrobenzofuran-2-carboxylic acid

Conditions
ConditionsYield
Stage #1: 2-(2-formyl-4-nitrophenoxy)acetic acid With acetic anhydride at 35℃; for 0.25h;
Stage #2: With sodium acetate at 125℃; for 8h;
Stage #1: 2-(2-formyl-4-nitrophenoxy)acetic acid With acetic anhydride at 35℃; for 0.25h;
Stage #2: With sodium acetate at 125℃; for 8h;
6-nitrocoumarin
2725-81-7

6-nitrocoumarin

5-nitrobenzofuran-2-carboxylic acid
10242-12-3

5-nitrobenzofuran-2-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium hydroxide / ethanol; water / 4 h / Reflux
2: copper dichloride; caesium carbonate / N,N-dimethyl-formamide / 5 h / 100 °C
View Scheme
5-nitrobenzofuran-2-carboxylic acid
10242-12-3

5-nitrobenzofuran-2-carboxylic acid

methyl 3-aminopropanoate hydrochloride
3196-73-4

methyl 3-aminopropanoate hydrochloride

C13H12N2O6

C13H12N2O6

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 25℃; for 48h; Inert atmosphere;100%
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 48h;
5-nitrobenzofuran-2-carboxylic acid
10242-12-3

5-nitrobenzofuran-2-carboxylic acid

chloroformic acid ethyl ester
541-41-3

chloroformic acid ethyl ester

(5-nitro-1-benzofuran-2-yl)methanol
90322-48-8

(5-nitro-1-benzofuran-2-yl)methanol

Conditions
ConditionsYield
With 4-methyl-morpholine; hydrogenchloride; sodium borohydrid In tetrahydrofuran; N,N-dimethyl-formamide91.2%
Methyl 3-aminobenzoate
4518-10-9

Methyl 3-aminobenzoate

5-nitrobenzofuran-2-carboxylic acid
10242-12-3

5-nitrobenzofuran-2-carboxylic acid

methyl 3-(5-nitro-1-benzofuran-2-amido)benzoate

methyl 3-(5-nitro-1-benzofuran-2-amido)benzoate

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 24h;86%
5-nitrobenzofuran-2-carboxylic acid
10242-12-3

5-nitrobenzofuran-2-carboxylic acid

tert-butyl 2-aminobenzylcarbamate
162046-50-6

tert-butyl 2-aminobenzylcarbamate

tert-butyl N-{[2-(5-nitro-1-benzofuran-2-amido)phenyl]methyl}carbamate

tert-butyl N-{[2-(5-nitro-1-benzofuran-2-amido)phenyl]methyl}carbamate

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 24h;85%
ethanol
64-17-5

ethanol

5-nitrobenzofuran-2-carboxylic acid
10242-12-3

5-nitrobenzofuran-2-carboxylic acid

ethyl 5-nitrobenzo[d]furan-2-carboxylate
69604-00-8

ethyl 5-nitrobenzo[d]furan-2-carboxylate

Conditions
ConditionsYield
With sulfuric acid for 2h; Reflux;84.2%
Thiomorpholin
123-90-0

Thiomorpholin

5-nitrobenzofuran-2-carboxylic acid
10242-12-3

5-nitrobenzofuran-2-carboxylic acid

(5-nitrobenzofuran-2-yl)(thiomorpholino)methanone

(5-nitrobenzofuran-2-yl)(thiomorpholino)methanone

Conditions
ConditionsYield
Stage #1: 5-nitrobenzofuran-2-carboxylic acid With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide for 0.25h;
Stage #2: Thiomorpholin In N,N-dimethyl-formamide at 20℃;
80%
5-nitrobenzofuran-2-carboxylic acid
10242-12-3

5-nitrobenzofuran-2-carboxylic acid

anthranilic acid amide
28144-70-9

anthranilic acid amide

N-(2-carbamoylphenyl)-5-nitro-1-benzofuran-2-carboxamide

N-(2-carbamoylphenyl)-5-nitro-1-benzofuran-2-carboxamide

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 24h;80%
5-nitrobenzofuran-2-carboxylic acid
10242-12-3

5-nitrobenzofuran-2-carboxylic acid

aniline
62-53-3

aniline

C15H10N2O4

C15H10N2O4

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 24h;79%
5-nitrobenzofuran-2-carboxylic acid
10242-12-3

5-nitrobenzofuran-2-carboxylic acid

2-carbomethoxyaniline
134-20-3

2-carbomethoxyaniline

methyl 2-(5-nitro-1-benzofuran-2-amido)benzoate

methyl 2-(5-nitro-1-benzofuran-2-amido)benzoate

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 24h;78%
5-nitrobenzofuran-2-carboxylic acid
10242-12-3

5-nitrobenzofuran-2-carboxylic acid

4-aminobenzamide
2835-68-9

4-aminobenzamide

C16H10N2O6

C16H10N2O6

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 24h;70%
5-nitrobenzofuran-2-carboxylic acid
10242-12-3

5-nitrobenzofuran-2-carboxylic acid

5-nitro-1-benzofuran-2-carboxamide
267644-49-5

5-nitro-1-benzofuran-2-carboxamide

Conditions
ConditionsYield
Stage #1: 5-nitrobenzofuran-2-carboxylic acid With oxalyl dichloride In dichloromethane; N,N-dimethyl-formamide at 20℃; for 2h;
Stage #2: With ammonium hydroxide at 0℃; for 0.166667h;
68%
Stage #1: 5-nitrobenzofuran-2-carboxylic acid With thionyl chloride; N,N-dimethyl-formamide In toluene at 35 - 115℃;
Stage #2: With ammonia at 10℃; pH=8 - 9;
Multi-step reaction with 2 steps
1: thionyl chloride / toluene; N,N-dimethyl-formamide / 0.5 h / 70 - 115 °C
2: ammonia / N,N-dimethyl-formamide / 10 °C / pH 8 - 9
View Scheme
5-nitrobenzofuran-2-carboxylic acid
10242-12-3

5-nitrobenzofuran-2-carboxylic acid

4-methoxycarbonyl aniline
619-45-4

4-methoxycarbonyl aniline

methyl 4-(5-nitro-1-benzofuran-2-amido)benzoate

methyl 4-(5-nitro-1-benzofuran-2-amido)benzoate

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 24h;66%
1,3-diethoxy-isopropanol
4043-59-8

1,3-diethoxy-isopropanol

5-nitrobenzofuran-2-carboxylic acid
10242-12-3

5-nitrobenzofuran-2-carboxylic acid

1,3-diethoxypropan-2-yl 5-nitro-1-benzofuran-2-carboxylate

1,3-diethoxypropan-2-yl 5-nitro-1-benzofuran-2-carboxylate

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In N,N-dimethyl-formamide at 50℃; for 14h;65%
5-nitrobenzofuran-2-carboxylic acid
10242-12-3

5-nitrobenzofuran-2-carboxylic acid

5-nitrobenzofuran-2-carboxylic Acid Methyl Ester
104862-11-5

5-nitrobenzofuran-2-carboxylic Acid Methyl Ester

methyl 5-acetamidobenzofuran-2-carboxylate
1646-30-6

methyl 5-acetamidobenzofuran-2-carboxylate

Conditions
ConditionsYield
With 2-(Dimethylamino)pyridine; acetic anhydride; sodium sulfate; palladium-carbon In water; ethyl acetate; acetone61%
2-[2-amino-4-(N-tert-butoxycarbonylamino)naphthalen-1-yl]ethyl acetate
413577-98-7

2-[2-amino-4-(N-tert-butoxycarbonylamino)naphthalen-1-yl]ethyl acetate

5-nitrobenzofuran-2-carboxylic acid
10242-12-3

5-nitrobenzofuran-2-carboxylic acid

2-[4-(N-t-butoxycarbonylamino)-2-(5-nitrobenzofuran-2-carboxamido)naphthalen-1-yl]ethyl acetate
413578-15-1

2-[4-(N-t-butoxycarbonylamino)-2-(5-nitrobenzofuran-2-carboxamido)naphthalen-1-yl]ethyl acetate

Conditions
ConditionsYield
With pyridine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride54%
With benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; 1-ethyl-3-(3-dimethylamino-propyl)-carbodiimide hydrochloride In pyridine at 20 - 60℃; for 120h;54%
5-nitrobenzofuran-2-carboxylic acid
10242-12-3

5-nitrobenzofuran-2-carboxylic acid

3-Aminobenzamide
3544-24-9

3-Aminobenzamide

N-(3-carbamoylphenyl)-5-nitro-1-benzofuran-2-carboxamide

N-(3-carbamoylphenyl)-5-nitro-1-benzofuran-2-carboxamide

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 24h;53%
ethyl 5-amino-1H-indole-2-carboxylate
71086-99-2

ethyl 5-amino-1H-indole-2-carboxylate

5-nitrobenzofuran-2-carboxylic acid
10242-12-3

5-nitrobenzofuran-2-carboxylic acid

ethyl 5-[(5-nitro-1H-benzofuran-2-ylcarbonyl)amino]-1H-indole-2-carboxylate
266348-99-6

ethyl 5-[(5-nitro-1H-benzofuran-2-ylcarbonyl)amino]-1H-indole-2-carboxylate

Conditions
ConditionsYield
With N-(3-dimethylaminopropyl)-N-ethylcarbodiimide In tetrahydrofuran; N,N-dimethyl-formamide at 20℃; Acylation;52%
With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In acetonitrile
5-nitrobenzofuran-2-carboxylic acid
10242-12-3

5-nitrobenzofuran-2-carboxylic acid

benzyl chloroformate
501-53-1

benzyl chloroformate

benzyl 5-nitrobenzofuran-2-ylcarbamate
1277175-54-8

benzyl 5-nitrobenzofuran-2-ylcarbamate

Conditions
ConditionsYield
With sodium azide; sodium t-butanolate In 1,2-dimethoxyethane at 75℃; for 20h; Curtius rearrangement; Inert atmosphere;49%
5-nitrobenzofuran-2-carboxylic acid
10242-12-3

5-nitrobenzofuran-2-carboxylic acid

(1R)-3-methyl-1-[(3aS,4S,6S,7aR)-3a,5,5-trimethylhexahydro-4,6-methano-1,3,2-benzodioxabor-ol-2-yl]butan-1-amine hydrochloride

(1R)-3-methyl-1-[(3aS,4S,6S,7aR)-3a,5,5-trimethylhexahydro-4,6-methano-1,3,2-benzodioxabor-ol-2-yl]butan-1-amine hydrochloride

(R)-(1-(5-nitrobenzofuran-2-carboxamido)-3-methylbutyl)boronic acid

(R)-(1-(5-nitrobenzofuran-2-carboxamido)-3-methylbutyl)boronic acid

Conditions
ConditionsYield
Stage #1: 5-nitrobenzofuran-2-carboxylic acid With benzotriazol-1-ol In dichloromethane at 20℃; for 0.166667h; Inert atmosphere;
Stage #2: (1R)-3-methyl-1-[(3aS,4S,6S,7aR)-3a,5,5-trimethylhexahydro-4,6-methano-1,3,2-benzodioxabor-ol-2-yl]butan-1-amine hydrochloride With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane for 15h;
Stage #3: With hydrogenchloride; Dihydroxy-isobutyl-boran In methanol; hexane; water at 20℃; for 5h;
48%
5-nitrobenzofuran-2-carboxylic acid
10242-12-3

5-nitrobenzofuran-2-carboxylic acid

2-fluoro-5-nitrobenzofuran

2-fluoro-5-nitrobenzofuran

Conditions
ConditionsYield
With potassium fluoride; Selectfluor In water; 1,2-dichloro-ethane at 70℃;40%
5-nitrobenzofuran-2-carboxylic acid
10242-12-3

5-nitrobenzofuran-2-carboxylic acid

2-(2-amino-4-benzyloxyphenyl)ethyl chloride
413577-26-1

2-(2-amino-4-benzyloxyphenyl)ethyl chloride

2-(4-benzyloxy-2-(5-nitrobenzofuran-2-carboxamido)phenyl)ethyl chloride
413577-33-0

2-(4-benzyloxy-2-(5-nitrobenzofuran-2-carboxamido)phenyl)ethyl chloride

Conditions
ConditionsYield
With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 48h;22%
With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In dichloromethane for 48h;
5-nitrobenzofuran-2-carboxylic acid
10242-12-3

5-nitrobenzofuran-2-carboxylic acid

C9H14N4O3

C9H14N4O3

C18H17N5O7

C18H17N5O7

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide Inert atmosphere;12%
methanol
67-56-1

methanol

5-nitrobenzofuran-2-carboxylic acid
10242-12-3

5-nitrobenzofuran-2-carboxylic acid

5-nitrobenzofuran-2-carboxylic Acid Methyl Ester
104862-11-5

5-nitrobenzofuran-2-carboxylic Acid Methyl Ester

Conditions
ConditionsYield
With hydrogenchloride
Stage #1: 5-nitrobenzofuran-2-carboxylic acid With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 0 - 20℃; for 1.66667h;
Stage #2: methanol With pyridine In dichloromethane at 0℃; Reagent/catalyst; Solvent;

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