Compounds derived from an amine nucleus that are inhibitors of IMPDH enzyme
The present invention discloses the identification of the novel inhibitors of IMPDH (inosine-5′-monophosphate dehydrogenase). The compounds and pharmaceutical compositions disclosed herein are useful in treating or preventing IMPDH mediated diseases, such as transplant rejection and autoimmune diseases.
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(2008/06/13)
Rapid synthesis of triazine inhibitors of inosine monophosphate dehydrogenase.
A series of novel triazine-based small molecule inhibitors (IV) of inosine monophosphate dehydrogenase was prepared. The synthesis and the structure-activity relationships (SAR) derived from in vitro studies are described.
Pitts, William J,Guo, Junqing,Dhar, T G Murali,Shen, Zhongqi,Gu, Henry H,Watterson, Scott H,Bednarz, Mark S,Chen, Bang Chi,Barrish, Joel C,Bassolino, Donna,Cheney, Daniel,Fleener, Catherine A,Rouleau, Katherine A,Hollenbaugh, Diane L,Iwanowicz, Edwin J
p. 2137 - 2140
(2007/10/03)
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