Rapid synthesis of triazine inhibitors of inosine monophosphate dehydrogenase.
A series of novel triazine-based small molecule inhibitors (IV) of inosine monophosphate dehydrogenase was prepared. The synthesis and the structure-activity relationships (SAR) derived from in vitro studies are described.
Pitts, William J,Guo, Junqing,Dhar, T G Murali,Shen, Zhongqi,Gu, Henry H,Watterson, Scott H,Bednarz, Mark S,Chen, Bang Chi,Barrish, Joel C,Bassolino, Donna,Cheney, Daniel,Fleener, Catherine A,Rouleau, Katherine A,Hollenbaugh, Diane L,Iwanowicz, Edwin J
p. 2137 - 2140
(2007/10/03)
A survey of cyclic replacements for the central diamide moiety of inhibitors of inosine monophosphate dehydrogenase
A series of heterocyclic replacements for the central diamide moiety of 1, a potent small molecule inhibitor of inosine monophosphate dehydrogenase (IMPDH) were explored. The synthesis and the structure-activity relationships (SARs), derived from in vitro
Dhar,Liu, Chunjian,Pitts, William J.,Guo, Junquing,Watterson, Scott H.,Gu, Henry,Fleener, Catherine A.,Rouleau, Katherine,Sherbina,Barrish, Joel C.,Hollenbaugh, Diane,Iwanowicz, Edwin J.
p. 3125 - 3128
(2007/10/03)
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