267880-87-5 Usage
Uses
Used in Pharmaceutical Industry:
2,3-Difluorobenzoylacetonitrile is used as a reactant for the preparation of benzoxazoyl amino cyanopyrimidines. These compounds serve as negative allosteric modulators of the mGlu5 receptor, which are being explored for their potential therapeutic effects on anxiety and addiction. The unique structural properties of 2,3-difluorobenzoylacetonitrile contribute to the development of these modulators, making it a valuable component in the synthesis process.
Check Digit Verification of cas no
The CAS Registry Mumber 267880-87-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,6,7,8,8 and 0 respectively; the second part has 2 digits, 8 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 267880-87:
(8*2)+(7*6)+(6*7)+(5*8)+(4*8)+(3*0)+(2*8)+(1*7)=195
195 % 10 = 5
So 267880-87-5 is a valid CAS Registry Number.
InChI:InChI=1/C9H5F2NO/c10-7-3-1-2-6(9(7)11)8(13)4-5-12/h1-3H,4H2
267880-87-5Relevant articles and documents
Fungal-Selective Resorcylate Aminopyrazole Hsp90 Inhibitors: Optimization of Whole-Cell Anticryptococcal Activity and Insights into the Structural Origins of Cryptococcal Selectivity
Marcyk, Paul T.,Leblanc, Emmanuelle V.,Kuntz, Douglas A.,Xue, Alice,Ortiz, Francisco,Trilles, Richard,Bengtson, Stephen,Kenney, Tristan M. G.,Huang, David S.,Robbins, Nicole,Williams, Noelle S.,Krysan, Damian J.,Privé, Gilbert G.,Whitesell, Luke,Cowen, Leah E.,Brown, Lauren E.
, p. 1139 - 1169 (2021/02/01)
The essential eukaryotic chaperone Hsp90 regulates the form and function of diverse client proteins, many of which govern thermotolerance, virulence, and drug resistance in fungal species. However, use of Hsp90 inhibitors as antifungal therapeutics has be
