269075-46-9

Basic information

• Product Name: (6-METHOXY-3-METHYL-1-BENZOFURAN-2-YL)(PHENYL)METHANONE
• Synonyms: (6-METHOXY-3-METHYL-1-BENZOFURAN-2-YL)(PHENYL)METHANONE;(6-methoxy-3-methylbenzofuran-2-yl)(phenyl)methanone
• CAS NO: 269075-46-9
• Molecular Formula: C₁₇H₁₄O₃
• Molecular Weight: 266.29
• Mol File: 269075-46-9.mol

Chemical Properties

• Melting Point: 76 °C
• Boiling Point: 392.8±37.0 °C(Predicted)
• Appearance: /
• Density: 1.184±0.06 g/cm3(Predicted)
• CAS DataBase Reference: (6-METHOXY-3-METHYL-1-BENZOFURAN-2-YL)(PHENYL)METHANONE(CAS DataBase Reference)
• NIST Chemistry Reference: (6-METHOXY-3-METHYL-1-BENZOFURAN-2-YL)(PHENYL)METHANONE(269075-46-9)
• EPA Substance Registry System: (6-METHOXY-3-METHYL-1-BENZOFURAN-2-YL)(PHENYL)METHANONE(269075-46-9)

Safety Data

• Hazardous Substances Data: 269075-46-9(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
(6-METHOXY-3-METHYL-1-BENZOFURAN-2-YL)(PHENYL)METHANONE is used as a building block in organic synthesis for the production of various pharmaceuticals and other organic compounds. Its unique structure allows for the creation of a wide range of molecules with diverse properties and applications.
Used in Pharmaceutical Research:
In the pharmaceutical industry, (6-METHOXY-3-METHYL-1-BENZOFURAN-2-YL)(PHENYL)METHANONE is used as a key intermediate in the development of new drugs. Its potential as an anti-inflammatory and analgesic agent has been recognized in preliminary studies, making it a promising candidate for further research and development.
Used in Anti-Inflammatory and Analgesic Applications:
(6-METHOXY-3-METHYL-1-BENZOFURAN-2-YL)(PHENYL)METHANONE has shown potential as an anti-inflammatory and analgesic agent in preliminary studies. It is used for its ability to help reduce inflammation and alleviate pain, making it a valuable compound in the development of new medications for these purposes.
Used as a Fluorescent Dye:
(6-METHOXY-3-METHYL-1-BENZOFURAN-2-YL)(PHENYL)METHANONE has been studied for its potential applications as a fluorescent dye. Its unique properties make it a candidate for use in various fields, including research, diagnostics, and imaging.
Used in Organic Electronic Devices:
In the field of organic electronics, (6-METHOXY-3-METHYL-1-BENZOFURAN-2-YL)(PHENYL)METHANONE has been investigated for its potential applications. Its unique structure and properties make it a promising candidate for use in the development of new electronic devices, such as organic light-emitting diodes (OLEDs) and organic photovoltaics (OPVs).

Upstream product

• 99246-62-5 2-benzoyl-3-methyl-6-hydroxybenzofuran 
• 74-88-4 methyl iodide 
• 29682-12-0 1-[4-(benzyloxy)-2-hydroxyphenyl]ethanone 
• 552-41-0 1-(2-hydroxy-4-methoxyphenyl)ethanone 
• 582-24-1 1-phenyl-2-hydroxyethanone 
• 532-27-4 1-chloroacetophenone 
• 70-11-1 α-bromoacetophenone 
• 855605-98-0 2-benzoyl-3-methyl-6-benzyloxybenzofuran 

Relevant articles and documents

Bi(OTf)3-Mediated (4+1) Annulation of α-Sulfonyl o-Hydroxyacetophenones with α-Hydroxy Arylketones to Access Sulfonyl 2-Aroylbenzofurans

In this paper, a high-yield, facile route for the scalable synthesis of sulfonyl 2-aroylbenzofurans via a Bi(OTf)3-mediated intermolecular double cyclocondensation of α-sulfonyl o-hydroxyacetophenones with substituted α-hydroxy arylketones under mild open-vessel reaction conditions is described. In the overall reaction, water is generated as the only byproduct. Various metal triflate-promoted reactions and conditions are investigated for the efficient one-pot (4+1) annulation reaction. (Figure presented.).

An easy access to benzofurans via DBU induced condensation reaction of active 2-hydroxy acetophenones with phenacyl chlorides: A novel class of antioxidant agents

A convenient and efficient one-pot synthesis of benzofurans 3a, 3b, 3c, 3d, 3e, 3f, 3g, 3h, 3i, 3j, 3k, 3l, 3m, 3n, 3o, 3p, 3q, 3r, 3s, 3t has been described from 2-hydroxy acetophenones and phenacyl chlorides in the presence of DBU. The procedure was applicable for a variety of phenacyl chlorides and provides a variety of benzofurans with higher yields. DBU acts as a base and as well as nucleophiles. All the derivatives were subjected to in vitro antioxidant screenings against representative 2,2'-diphenyl-1-picryl-hydrazyl and 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) radicals and results worth for further investigations.

Facile microwave-assisted synthesis of substituted benzofuran derivatives

A series of benzofuran derivatives have been synthesized by use of a microwave-assisted process. Substituted or unsubstituted ?- hydroxyacetophenone and salicylaldehyde reacted with ethyl bromoacetate, ω-bromoacetophenone, or chloroacetone under the action of potassium carbonate in DMF to yield substituted benzofuran derivatives. Compared with conventional heating, this microwave-assisted synthetic process has the advantages of more convenient operation, shorter reaction time, and higher yield.

Synthesis and?antifungal activities of?some?aryl [3-(imidazol-1-yl/triazol-1-ylmethyl) benzofuran-2-yl] ketoximes

In this study, some aryl [3-(imidazol-1-yl/triazol-1-ylmethyl)benzofuran-2-yl] ketones, aryl (3-methyl-benzofuran-2-yl) ketoximes and aryl [3-(imidazol-1-yl/triazol-1-ylmethyl)benzofuran-2-yl] ketoximes were synthesised starting from 2-aryloyl-3-methyl-be

Synthesis and analgesic activity of some 1-benzofurans, 1-benzothiophenes and indoles

3-Unsubstituted 1-benzofurans 1e and 1f, 3-methyl-1-benzofurans 1a-1d, and 3-amino-1-benzofurans 2a-21, as well as 3-amino-1-benzothiophenes 3a, 3b and 3-aminoindoles 4a-4f, 11a, and 11b were prepared and tested as analgesics. The 3-amino-1-benzofurans 2 were prepared from the corresponding 2-hydroxybenzonitriles 5 and phenacyl bromides 6 via intermediates 7. Similar treatment of 2-sulfanylbenzonitrile (8) provided 3-amino-1-benzothiophenes 3. Appropriately substituted 2-aminobenzonitriles 9 then provided N-substituted 3-aminoindoles 4. 1-(Ethoxycarbonyl)indoles 4e and 4f were successfully deprotected giving indoles 11a and 11b, respectively.