855605-98-0Relevant articles and documents
Design, synthesis, and biological activity of a novel series of benzofuran derivatives against oestrogen receptor-dependent breast cancer cell lines
Hu, Chun,Hu, Jian-Shu,Huang, Er-Fang,Jin, Li-Ping,Jin, Zhe,Wan, David Chi-Cheong,Wang, Lin,Xie, Qian,Zhang, Bing-Qi
, (2020)
A docking study of a novel series of benzofuran derivatives with ERα was conducted. In this study, we report the synthesis of a novel series of benzofuran derivatives and evaluation of their anticancer activity in vitro against MCF-7 human breast cancer cells, as well as their potential toxicity to ER-independent MDA-MB-231 breast cancer cells, human renal epithelial HEK-293 cells, and human immortal keratinocytes (HaCaT cells) by using the MTT colorimetric assay. The screening results indicated that the target compounds exhibited anti-breast cancer activity. The target compound 2-benzoyl-3-methyl-6-[2-(morpholin-4-yl)ethoxy]benzofuran hydrochloride (4e) exhibited excellent activity against anti-oestrogen receptor-dependent breast cancer cells and low toxicity. The preliminary structure-activity relationships of the target benzofuran derivatives have been summarised. In conclusion, the novel benzofuran scaffold may be a promising lead for the development of potential oestrogen receptor inhibitors.
6-[2-hydroxyl-3-(alkylamino)propoxy]benzofuran compound and application thereof
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, (2018/05/16)
The invention belongs to the technical field of medicines and relates to a 6-[2-hydroxyl-3-(alkylamino)propoxy]benzofuran compound and an application thereof. The 6-[2-hydroxyl-3-(alkylamino)propoxy]benzofuran compound comprises a stereoisomer and pharmacologically applicable salt of the compound and has the general structural formula shown in the description, wherein R is shown in the claims andspecification. The 6-[2-hydroxyl-3-(alkylamino)propoxy]benzofuran compound and the pharmacologically applicable salt-additive salt of the compound can be mixed with an existing medicine for use or used alone to be applied to a medicine for treating spastic diseases of vascular smooth muscle.
