- Studies of precursor-directed biosynthesis with streptomyces, 3. - Structural diversity of 1-O-acyl α-L-rhamnopyranosides by precursor-directed biosynthesis with Streptomyces griseoviridis
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The ability of Streptomyces griseoviridis (strain Tu 3634) to glycosylate various carboxylic acids with 1-rhamnose was investigated by feeding mainly heteroaromatic and aromatic carboxylic acids to growing cultures. The special application of the precursor-directed biosynthesis (PDB) gave rise to a wide variety of acyl α-L-rhamnopyranosides as novel metabolites. The experiments resulted in furanyl, pyrrolyl, thienyl, indolyl, and pyridyl derivatives (1-8), the analogues 9-24 were generated by feeding fluoro-, hydroxy- or aminobenzoic acids or cinnamic acids. All results are discussed with respect to the substrate specificity of the corresponding enzyme system.
- Grond, Stephanie,Papastavrou, Ina,Zeeck, Axel
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p. 1875 - 1881
(2007/10/03)
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