A versatile method for the preparation of 2,2-disubstituted morpholine analogues
We describe a versatile synthetic method for the preparation of 2,2- disubstituted morpholine analogues. Iodo-etherification of 1,1-disubstituted olefin with N-Boc-aminoethanol using NIS proceeded smoothly in a regioselective manner and the following cyclization was accomplished in good yield. We successfully applied this method for the preparation of the key intermediate 2 of tachykinin receptor antagonist. (C) 2000 Elsevier Science Ltd.
Takemoto, Toshiyasu,Iio, Yukiko,Nishi, Takahide
p. 1785 - 1788
(2007/10/03)
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